{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:37:38Z","timestamp":1790311058031,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1977,6,1]],"date-time":"1977-06-01T00:00:00Z","timestamp":233971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1977,6]]},"abstract":"<jats:p>1. The p.d. of rat seminiferous tubules was 5\u00b786 \u00b1 0\u00b715 mV, lumen negative, at 33\u00b0 C and varied linearly with temperature between 24 and 37\u00b0 C, exhibiting an apparent <jats:italic>Q<\/jats:italic><jats:sub>10<\/jats:sub><jats:sup>25-35\u00b0 C<\/jats:sup> of 2\u00b70 with a slope of 0\u00b743 mV\/\u00b0 C. Exposing testes to a temperature of 37\u201043\u00b0 C resulted in an initial hyperpolarization followed by depolarization of the tubules. These changes were more rapid in testes exposed to 41\u201043\u00b0 C than in testes exposed to 37\u201039\u00b0 C.<\/jats:p><jats:p>2. The <jats:italic>R<\/jats:italic><jats:sub>in<\/jats:sub> of seminiferous tubules was 198 \u00b1 7\u00b78 k\u03a9 at a testis temperature of 33\u00b0 C. The <jats:italic>R<\/jats:italic><jats:sub>in<\/jats:sub> decreased when testes were maintained at 37 and 41\u00b0 C, the rate of decrease being similar to the rate of depolarization.<\/jats:p><jats:p>3. Exposing testes to deep body temperature by unilateral surgical cryptorchidism caused a reduction of 30 and 64% in tubular p.d. and <jats:italic>R<\/jats:italic><jats:sub>in<\/jats:sub> respectively when measured 24 hr after surgery. Exposure to deep body temperature for up to 4 days did not cause any further change in either parameter.<\/jats:p><jats:p>4. There was no evidence that lanthanum penetrated through the Sertoli cell tight junctions after exposing testes to 41\u00b0 C for up to 30 min.<\/jats:p><jats:p>5. The results indicate that the seminiferous tubule p.d. is maintained by a temperature\u2010sensitive, cellular mechanism. Exposing testes to deep body temperature or above depolarized the tubules and increased their permeability.<\/jats:p>","DOI":"10.1113\/jphysiol.1977.sp011849","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T08:47:57Z","timestamp":1418978877000},"page":"111-121","source":"Crossref","is-referenced-by-count":5,"title":["The effect of temperature on the potential difference and input resistance of rat seminiferous tubules"],"prefix":"10.1113","volume":"268","author":[{"given":"R. T.","family":"Gladwell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1977,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1977.sp011849","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1977.sp011849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T21:07:33Z","timestamp":1699218453000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1977.sp011849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,6]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,6]]}},"alternative-id":["10.1113\/jphysiol.1977.sp011849"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1977.sp011849","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,6]]}}}