{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T21:40:32Z","timestamp":1699220432747},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1977,6,1]],"date-time":"1977-06-01T00:00:00Z","timestamp":233971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1977,6]]},"abstract":"<jats:p>1. Isolated rat superior cervical ganglia were continuously superfused with <jats:sup>42<\/jats:sup>K (or <jats:sup>86<\/jats:sup>Rb) solution and the amount of radioactivity taken up was monitored using scintillation counting.<\/jats:p><jats:p>2. Entry of <jats:sup>42<\/jats:sup>K into the ganglia could be resolved into two components, one amounting to 83% of the total <jats:sup>42<\/jats:sup>K uptake, with a rate constant of 0\u00b7015 min<jats:sup>\u22121<\/jats:sup>, and the other of 17% of the total, with a rate constant of 0\u00b715 min<jats:sup>\u22121<\/jats:sup>.<\/jats:p><jats:p>3. With 6 m\n<jats:sc>M<\/jats:sc>\u2010K in the bathing solution, the equilibrium uptake of <jats:sup>42<\/jats:sup>K after 4 hr corresponded to an intracellular concentration of 147 m\n<jats:sc>M<\/jats:sc>\u2010K. Changes in the K concentration of the bathing solution (0\u00b75\u201020 m\n<jats:sc>M<\/jats:sc>) had little effect on this value.<\/jats:p><jats:p>4. Carbachol or nicotine caused a rapid net loss of <jats:sup>42<\/jats:sup>K. <jats:sup>42<\/jats:sup>K was recaptured on washing out the depolarizing agents, with a rate constant of about 0\u00b73 min<jats:sup>\u22121<\/jats:sup>. This recapture rate was slowed by ouabain, dinitrophenol, cyanide, mersalyl and by reducing the K concentration in the bathing solution.<\/jats:p><jats:p>5. Efflux of <jats:sup>42<\/jats:sup>K from preloaded ganglia occurred with a rate constant of 0\u00b7017 min<jats:sup>\u22121<\/jats:sup>. This rate was increased about sixfold by 180 \u03bc\n<jats:sc>M<\/jats:sc> carbachol in 6 m\n<jats:sc>M<\/jats:sc>\u2010K but not in 150 m\n<jats:sc>M<\/jats:sc>\u2010K suggesting that the increase in efflux was mainly a consequence of the depolarization caused by carbachol.<\/jats:p><jats:p>6. <jats:sup>86<\/jats:sup>Rb fluxes and the effects of carbachol thereon were similar.<\/jats:p>","DOI":"10.1113\/jphysiol.1977.sp011850","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T08:47:57Z","timestamp":1418978877000},"page":"123-137","source":"Crossref","is-referenced-by-count":4,"title":["Movements of radioactive potassium in isolated rat ganglia"],"prefix":"10.1113","volume":"268","author":[{"given":"C. N.","family":"Scholfield","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1977,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1977.sp011850","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1977.sp011850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T21:07:27Z","timestamp":1699218447000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1977.sp011850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,6]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,6]]}},"alternative-id":["10.1113\/jphysiol.1977.sp011850"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1977.sp011850","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,6]]}}}