{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T05:30:33Z","timestamp":1770442233211,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1977,8,1]],"date-time":"1977-08-01T00:00:00Z","timestamp":239241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1977,8]]},"abstract":"<jats:p>1. Gastrin activates rat stomach histidine decarboxylase. Exogenous histamine suppressed the basal enzyme activity in unoperated, in nephrectomized, in vagally denervated and in antrectomized rats, and counteracted the pentagastrin\u2010induced enzyme activation in unoperated rats.<\/jats:p><jats:p>2. Kinetic analysis of enzyme\u2010catalysed histidine decarboxylation in extracts from untreated vagotomized and from histamine\u2010treated vagotomized rats showed that the histamine\u2010induced suppression of histidine decarboxylase activity probably reflects a reduced enzyme concentration. Moreover, the enzyme half\u2010life in vagotomized rats after treatment with histamine was shorter than the half\u2010life observed after inhibition of enzyme synthesis. These observations suggest that administration of histamine not only inhibits enzyme synthesis but also causes an accelerated rate of elimination of histidine decarboxylase.<\/jats:p><jats:p>3. Intravenous infusion of histamine caused marked displacement of the pentagastrin dose\u2014response curve, in a manner suggesting a reduced sensitivity to pentagastrin.<\/jats:p><jats:p>4. After H<jats:sub>2<\/jats:sub>\u2010receptor blockade, but not after H<jats:sub>1<\/jats:sub>\u2010receptor blockade, histamine was less effective in suppressing the enzyme activity. Furthermore, H<jats:sub>2<\/jats:sub>\u2010receptor blockade augmented the pentagastrin\u2010induced enzyme activation.<\/jats:p><jats:p>5. The results suggest that histamine (via H<jats:sub>2<\/jats:sub>\u2010receptors) reduces the sensitivity of the histamine\u2010storing cells to gastrin and that H<jats:sub>2<\/jats:sub>\u2010receptor blockade induces the opposite effects.<\/jats:p><jats:p>6. We propose that the histamine\u2010storing cells in the rat stomach are endowed with H<jats:sub>2<\/jats:sub>\u2010receptors and that exogenous histamine is capable of acting directly on the histamine cells. This may reflect a physiological control mechanism whereby mobilized endogenous histamine modifies its own synthesis and release.<\/jats:p>","DOI":"10.1113\/jphysiol.1977.sp011920","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T08:38:43Z","timestamp":1418978323000},"page":"643-667","source":"Crossref","is-referenced-by-count":41,"title":["Suppression of rat stomach histidine decarboxylase activity by histamine: H<sub>2<\/sub>\u2010receptor\u2010mediated feed\u2010back"],"prefix":"10.1113","volume":"269","author":[{"given":"R.","family":"H\u00e5kanson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.-I.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Liedberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Rehfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Sundler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1977,8]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1977.sp011920","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1977.sp011920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T17:23:26Z","timestamp":1699205006000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1977.sp011920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,8]]}},"alternative-id":["10.1113\/jphysiol.1977.sp011920"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1977.sp011920","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,8]]}}}