{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:33:48Z","timestamp":1752230028508},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1977,8,1]],"date-time":"1977-08-01T00:00:00Z","timestamp":239241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1977,8]]},"abstract":"<jats:p>1. Synaptic potentials evoked by electrical stimulation of cranial nerves were recorded in giant reticulospinal neurones (M\u00fcller cells) of lamprey. A variety of patterns of stimulation was employed to explore further the functional properties of the pathways intervening between the cranial nerve fibres and M\u00fcller cells.<\/jats:p><jats:p>2. Simultaneous low intensity stimulation of two different cranial nerves produced excitatory short\u2010latency synaptic potentials whose amplitudes summed linearly.<\/jats:p><jats:p>3. Tetanic (10\/sec) stimulation of a cranial nerve depressed the evoked short\u2010latency synaptic response, but following the tetanus the synaptic response was potentiated above control amplitude for several minutes. Tetanic stimulation of one cranial nerve had no effect upon the synaptic responses evoked by stimulation of other cranial nerves.<\/jats:p><jats:p>4. Low\u2010frequency stimulation (1\/sec to 1\/20 sec) of a cranial nerve produced a progressive decrease in the amplitude of the evoked short\u2010latency synaptic response. This phenomenon was termed synaptic habituation because its characteristics were functionally similar to behavioural habituation in animals.<\/jats:p><jats:p>5. Habituation of the synaptic response to stimulation of one cranial nerve had no effect on the synaptic responses produced by stimulation of other cranial nerves.<\/jats:p><jats:p>6. Synaptic afterdischarges lasting from several seconds to several minutes were recorded in M\u00fcller cells. They occurred both spontaneously and in response to strong electrical stimulation of cranial nerves. For several minutes following an afterdischarge the amplitudes of short\u2010latency synaptic potentials produced by stimulation of any one of the cranial nerves were increased as much as twofold. This facilitation occurred equally well whether the short\u2010latency synaptic responses had been habituated or not.<\/jats:p><jats:p>7. A theoretical cell\u2010wiring diagram is proposed to account for the properties of short\u2010latency evoked synaptic responses and synaptic afterdischarges and for the facilitation of short\u2010latency responses by afterdischarges.<\/jats:p>","DOI":"10.1113\/jphysiol.1977.sp011941","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T08:27:12Z","timestamp":1418977632000},"page":"115-131","source":"Crossref","is-referenced-by-count":16,"title":["Post\u2010tetanic potentiation, habituation and facilitation of synaptic potentials in reticulospinal neurones of lamprey"],"prefix":"10.1113","volume":"270","author":[{"given":"Warren O.","family":"Wickelgren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1977,8]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1977.sp011941","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1977.sp011941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T16:50:37Z","timestamp":1699203037000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1977.sp011941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,8]]}},"alternative-id":["10.1113\/jphysiol.1977.sp011941"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1977.sp011941","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,8]]}}}