{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:09:17Z","timestamp":1771628957179,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1977,12,1]],"date-time":"1977-12-01T00:00:00Z","timestamp":249782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1977,12]]},"abstract":"<jats:p>1. Transient changes of heart rate (HR) and ventilation were recorded following step changes in alveolar gas composition in three healthy subjects. From a steady state of normo\u2010 or slightly hypercapnic hypoxia (PA,CO2 38\u201046 torr, PA,O2 50\u201060 torr) arterial chemoreceptor stimulation was transiently relieved by breathing a CO2\u2010free mixture for two breaths, either pur O2 (causing a fall in PA,CO2 and a rise in PA,O2; O2 test) or a low O2 mixture (causing a fall in PA,CO2 without any change in PA, O2; CO2 test). For both test types ventilation was either allowed to change freely ('free\u2010breathing' tests) or was consciously maintained at the pre\u2010test level by the subjects ('controlled\u2010breathing tests). The circulatory delay from the lungs to the ear was measured with a sensitive ear oximeter. 2. In all 'free\u2010breathing' tests ventilation decreased significantly after a mean latency of 5.2 sec; the average lung\u2010ear circulation time was 4.9 sec. HR increased slightly above pre\u2010test levels in eighty\u2010one of one hundred and four tests of all types, the changes being significant after a latency identical to that of the ventilatory changes. Except in the 'controlled\u2010breathing' CO2 tests this early tachycardia was followed by a decrease in HR within the following 5\u20106 sec. 3.These findings indicate that the primary effect of withdrawal of arterial chemoreceptor stimulation in conscious man as in the anesthetized animal is tachycardia. The secondary development of bradycardia in 'free\u2010breathing' CO2 tests is probably due to the operation of a lung reflex sensing changes in ventilation. The absence of bradycardia in 'controlled\u2010breathing' CO2 tests and its presence in 'controlled\u2010breathing' O2 tests, finally, suggest that relief of systemic hypoxia causes a slowing of the heart not due to lung reflexes but to some other mechanism which operates with a latency nearly twice as long as the arterial chemoreflex.<\/jats:p>","DOI":"10.1113\/jphysiol.1977.sp012084","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T08:15:35Z","timestamp":1418976935000},"page":"109-120","source":"Crossref","is-referenced-by-count":13,"title":["Arterial chemoreceptors, ventilation and heart rate in man."],"prefix":"10.1113","volume":"273","author":[{"given":"D B","family":"Drysdale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E S","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1977,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1977.sp012084","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1977.sp012084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T05:46:29Z","timestamp":1699249589000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1977.sp012084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,12]]}},"alternative-id":["10.1113\/jphysiol.1977.sp012084"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1977.sp012084","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,12]]}}}