{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:36:16Z","timestamp":1771644976041,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1978,1,1]],"date-time":"1978-01-01T00:00:00Z","timestamp":252460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:p>1. The effects of \u03b1\u2010 and \u03b2\u2010adrenoceptor agonists and antagonists on chemosensory discharges originating from carotid bodies <jats:italic>in situ<\/jats:italic> were studied in anaesthetized cats.<\/jats:p><jats:p>2. Noradrenaline (NA) injections commonly resulted in increased frequency of carotid nerve chemosensory discharge, an effect ascribed to reduced blood flow through the glomus, and reduced or eliminated by \u03b1\u2010adrenergic block.<\/jats:p><jats:p>3. NA injections occasionally produced an initial reduction of chemosensory discharge frequency, which was however less intense and of shorter duration than that caused by dopamine. This effect of NA is not mediated by \u03b1\u2010adrenoceptors, since it is not blocked by dibenamine, but probably by low affinity for dopamine receptors.<\/jats:p><jats:p>4. Dopamine and apomorphine\u2010elicited chemosensory inhibition were not affected by low doses of phenoxybenzamine, which blocked NA\u2010evoked hypertensive reactions.<\/jats:p><jats:p>5. Higher doses of phenoxybenzamine and dibenamine produced a displacement to the right of dose\u2014response curves for dopamine\u2010 and apormorphine\u2010elicited chemosensory inhibition. However, this interference by \u03b1\u2010adrenergic blockers was attributed to the resultant hypotension, since it was reversed upon restoration of blood pressure.<\/jats:p><jats:p>6. Isoprenaline, a \u03b2\u2010adrenergic agonist, did not induce chemosensory inhibition, whilst \u03b2\u2010adrenergic blockers (propranolol and dichloroisoproterenol) did not modify dopamine\u2010 and apomorphine\u2010elicited chemosensory inhibition.<\/jats:p><jats:p>7. These results provide further support for the hypothesis that chemosensory inhibition could be mediated by specific dopamine receptors, distinct from \u03b1\u2010 and \u03b2\u2010adrenoceptors.<\/jats:p>","DOI":"10.1113\/jphysiol.1978.sp012163","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T08:06:47Z","timestamp":1418976407000},"page":"501-509","source":"Crossref","is-referenced-by-count":42,"title":["Effects of adrenoceptor stimulating and blocking agents on carotid body chemosensory inhibition"],"prefix":"10.1113","volume":"274","author":[{"given":"F.","family":"Llados","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Zapata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1978,1]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1978.sp012163","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1978.sp012163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T15:49:24Z","timestamp":1699199364000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1978.sp012163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,1]]}},"alternative-id":["10.1113\/jphysiol.1978.sp012163"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1978.sp012163","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,1]]}}}