{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:38:17Z","timestamp":1760783897370},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1978,2,1]],"date-time":"1978-02-01T00:00:00Z","timestamp":255139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1978,2]]},"abstract":"<jats:p>1. The effects of different external ionic conditions and of metabolic inhibitors on the membrane potential of hyperpolarizing photoreceptors in the retina of the scallop <jats:italic>Pecten irradians<\/jats:italic> were examined in the presence and absence of light.<\/jats:p><jats:p>2. Changes in extracellular K<jats:sup>+<\/jats:sup> have a greater effect on membrane potential in the light than in darkness. The receptor potential is increased in amplitude when [K]<jats:sub>o<\/jats:sub> is reduced and decreased when [K]<jats:sub>o<\/jats:sub> is elevated. It is hyperpolarizing when [K]<jats:sub>o<\/jats:sub> is less than the estimated value for [K]<jats:sub>i<\/jats:sub> and depolarizing when this condition is reversed.<\/jats:p><jats:p>3. The complete replacement of [Na]<jats:sub>o<\/jats:sub> causes a significant hyperpolarization of membrane potential in darkness, whereas it has a much smaller hyperpolarizing effect on the peak of the receptor potential.<\/jats:p><jats:p>4. The ratio of Na<jats:sup>+<\/jats:sup> to K<jats:sup>+<\/jats:sup> permeabilities (<jats:italic>P<\/jats:italic><jats:sub>Na<\/jats:sub>\/<jats:italic>P<\/jats:italic><jats:sub>K<\/jats:sub>) decreases during bright illumination. Our results suggest that <jats:italic>P<\/jats:italic><jats:sub>K<\/jats:sub> is seven times that for <jats:italic>P<\/jats:italic><jats:sub>Na<\/jats:sub> in the dark but is 57 times greater than <jats:italic>P<\/jats:italic><jats:sub>Na<\/jats:sub> in light.<\/jats:p><jats:p>5. The metabolic inhibitors DNP and NaCN cause membrane potential in the dark to hyperpolarize. This hyperpolarization is associated with a decrease in the <jats:italic>P<\/jats:italic><jats:sub>Na<\/jats:sub>\/<jats:italic>P<\/jats:italic><jats:sub>K<\/jats:sub> ratio similar to that found during illumination.<\/jats:p><jats:p>6. High [Ca<jats:sup>+<\/jats:sup>]<jats:sub>o<\/jats:sub> also causes membrane potential in the dark to hyperpolarize. This hyperpolarization is associated with an increase in membrane conductance.<\/jats:p><jats:p>7. The results indicate that the hyperpolarizing receptor potential of the distal photoreceptor is produced by a light\u2010evoked increase in K<jats:sup>+<\/jats:sup> permeability.<\/jats:p>","DOI":"10.1113\/jphysiol.1978.sp012193","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T08:04:54Z","timestamp":1418976294000},"page":"345-355","source":"Crossref","is-referenced-by-count":25,"title":["Ionic effects on the membrane potential of hyperpolarizing photoreceptor in scallop retina"],"prefix":"10.1113","volume":"275","author":[{"given":"A. L. F.","family":"Gorman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"McReynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1978,2]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1978.sp012193","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1978.sp012193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T22:46:58Z","timestamp":1699224418000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1978.sp012193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,2]]}},"alternative-id":["10.1113\/jphysiol.1978.sp012193"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1978.sp012193","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,2]]}}}