{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:18:00Z","timestamp":1757542680989},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1978,7,1]],"date-time":"1978-07-01T00:00:00Z","timestamp":268099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1978,7]]},"abstract":"<jats:p>1. A study was performed of the L\u2010glutamate, gamma\u2010aminobutyric acid (GABA), and acetylcholine (ACh) responses of cells in the stomatogastric ganglion of the crab, Cancer pagurus. 2. Ionophoretic or pressure application of L\u2010glutamate revealed three classes of responses: a K+\u2010dependent inhibition which reversed at 15\u201020 mV more negative than the resting potential; a Cl\u2010 dependent inhibitory response which was at equilibrium at the resting potential; and a depolarizing response. 3. Ionophoretic or pressure applications of GABA likewise produced three kinds of responses: an increase in K+ conductance, an increase in Cl\u2010 conductance, and a depolarizing response. 4. Picrotoxin (10(\u20106)\u201010(\u20105) M) was effective in blocking both the glutamate inhibitory responses. 10(\u20104) M\u2010picrotoxin, which was necessary to produce a 50% block of the GABA\u2010K+\u2010dependent response, had no effect on the GABA\u2010Cl\u2010 response. 5. beta\u2010Guanidinopropionic acid (beta\u2010GP) was found to be an agonist for the GABA\u2010K+ response, but was ineffective in mimicking or blocking the GABA\u2010Cl\u2010 response. 6. ACh applications produced large depolarizing responses with a pharmacological profile similar to that of the nicotinic ganglionic response in vertebrates. 7. The muscarinic agonist, acetyl\u2010beta\u2010methyl choline (MeCh), produced depolarizations which decreased in amplitude as the membrane was hyperpolarized from \u201040 to \u2010100 mV. Pilocarpine and oxotremorine produced changes in the endogenous activity of ganglionic neurones. 8. Implications of these results for the identification of synaptic transmitters in the somatogastric ganglion are discussed.<\/jats:p>","DOI":"10.1113\/jphysiol.1978.sp012381","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:53:34Z","timestamp":1418975614000},"page":"213-236","source":"Crossref","is-referenced-by-count":132,"title":["The pharmacological properties of some crustacean neuronal acetylcholine, gamma\u2010aminobutyric acid, and L\u2010glutamate responses."],"prefix":"10.1113","volume":"280","author":[{"given":"E","family":"Marder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Paupardin-Tritsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1978,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1978.sp012381","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1978.sp012381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T06:54:01Z","timestamp":1699167241000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1978.sp012381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,7]]}},"alternative-id":["10.1113\/jphysiol.1978.sp012381"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1978.sp012381","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,7]]}}}