{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T18:14:23Z","timestamp":1716574463930},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1978,8,1]],"date-time":"1978-08-01T00:00:00Z","timestamp":270777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1978,8]]},"abstract":"<jats:p>1. At 30 \u00b0C ambient temperature <jats:italic>E. coli<\/jats:italic> endotoxin injected into the cerebral ventricles evokes a febrile response in 0\u20103 day\u2010old guinea\u2010pigs. If the dose is sufficiently high, the fever is biphasic: two rising phases separated by a transient fall.<\/jats:p><jats:p>2. At 20 \u00b0C ambient temperature the change in body temperature after the endotoxin is still biphasic, but the transient fall is more pronounced and, finally, hypothermia develops. The relatively large surface area of the new\u2010born cannot explain, by itself, the hypothermia.<\/jats:p><jats:p>3. The phasic changes in body temperature following endotoxin administration are unlikely to be mediated by a single central factor, and a sequence of several factors could be postulated.<\/jats:p><jats:p>4. Indomethacin prevents the first\u2010phase febrile rise in body temperature, and also the consequent fall, but not the second\u2010phase rise.<\/jats:p><jats:p>5. <jats:italic>p<\/jats:italic>\u2010Chlorophenylalanine pre\u2010treatment prevents the transient fall only, it slightly increases the first\u2010phase rise and does not influence the second\u2010phase rise.<\/jats:p><jats:p>6. Prostaglandins and\/or other derivatives of endogenous arachidonic acid in the brain might be responsible for the first rising phase of the endotoxin fever, and might also initiate a central serotonergic mechanism which, in turn, could lead to the transient falling phase between the two rising phases of fever. The mechanism of the second\u2010phase febrile rise in body temperature awaits some other explanation.<\/jats:p>","DOI":"10.1113\/jphysiol.1978.sp012433","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:53:11Z","timestamp":1418975591000},"page":"467-476","source":"Crossref","is-referenced-by-count":12,"title":["Endotoxin fever in the new\u2010born guinea\u2010pig and the modulating effects of indomethacin and <i>p<\/i>\u2010chlorophenylalanine"],"prefix":"10.1113","volume":"281","author":[{"given":"M.","family":"Sz\u00e9kely","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1978,8]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1978.sp012433","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1978.sp012433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T10:30:50Z","timestamp":1699180250000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1978.sp012433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,8]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,8]]}},"alternative-id":["10.1113\/jphysiol.1978.sp012433"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1978.sp012433","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,8]]}}}