{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:56:10Z","timestamp":1758279370042},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1979,2,1]],"date-time":"1979-02-01T00:00:00Z","timestamp":286675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1979,2]]},"abstract":"<jats:p>1. From a 150 mM\u2010NH4 salicylate medium salicylate enters human red cells with a rate constant of 1.9 min\u20101 at 0 degrees C. 2. Salicylate increases the red cell permeability for Ca2+ (and Mg2+). There is no saturation of the Ca2+ transfer with respect to salicylate up to 150 mM and with respect to external Ca2+ up to 30 mM. 3. Ca2+ entering from salicylate media activates the Ca\u2010sensitive K channel present in human but not in adult ruminant red cells. 4. The increase in K permeability which ensues hyperpolarizes the membrane in Na salicylate media, accelerating further Ca2+ entry and Mg2+ entry and favouring Cl\u2010 loss (see Fig. 8). The Ca2+ inward movement is in agreement with the constant field equation if the membrane potential is assumed to equal the K equilibrium potential and if two charges are attributed to the mobile species. 5. The effect of salicylate on Ca2+ permeability and hence its sequelae are reversible upon washing the cells. 6. 3\u2010OH\u2010benzoic acid and 4\u2010OH\u2010benzoic acid do not exert the effect salicylate has on Ca2+ permeability. 7. In 150 mM\u2010Na salicylate media the Cl\u2010\u2010salicylate exchange is virtually nil at 0 degrees C. The exchange seen at 19 degrees C is obviously not across the anion exchange mechanism and proceeds at a rate comparable to that for Cl\u2010 movement in the nonexchange\u2010restricted mode given by Hunter (1971, 1977) for cells in a normal medium. 8. Ca2+ seems to increase the Cl\u2010 permeability seen under these conditions. 9. The possibility that salicylate acts as an ionophore for Ca2+ is discussed.<\/jats:p>","DOI":"10.1113\/jphysiol.1979.sp012642","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:32:27Z","timestamp":1418974347000},"page":"15-32","source":"Crossref","is-referenced-by-count":27,"title":["The relation between net calcium, alkali cation and chloride movements in red cells exposed to salicylate."],"prefix":"10.1113","volume":"287","author":[{"given":"H","family":"B\u00fcrgin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Schatzmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1979,2]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1979.sp012642","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1979.sp012642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T15:30:20Z","timestamp":1699198220000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1979.sp012642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,2]]}},"alternative-id":["10.1113\/jphysiol.1979.sp012642"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1979.sp012642","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,2]]}}}