{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:44:33Z","timestamp":1771627473948,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1979,6,1]],"date-time":"1979-06-01T00:00:00Z","timestamp":297043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1979,6]]},"abstract":"<jats:p>1. The metabolism of 5\u2010hydroxytryptamine (5\u2010HT) in homogenates of lung and in perfused isolated lungs, was measured, using [14C]5\u2010HT, over the 4\u2010day oestrous cycle in rats. 2. In lung homogenates, 5\u2010HT metabolism (reflecting monoamine oxidase (MAO) activity) was greater during met\u2010oestrus than during the rest of the cycle. 3. In homogenates, the apparent Km for MAO activity was lowest during met\u2010oestrus whereas the, Vmax value was highest during di\u2010oestrus. 4. In perfused lungs, 5\u2010HT metabolism and uptake was greater during pro\u2010oestrus than during met\u2010oestrus. 5. In lung homogenates prepared from female rats treated with 17 beta\u2010oestradiol or progesterone for 8 days, the metabolism of 5\u2010HT was increased. 6. We conclude that although the lung is not usually considered a target organ for ovarian hormones, its metabolic activity is affected by changes in the levels of endogenous or exogenous ovarian steroids, an effect comparable with those already observed in uterus, ovary and other more commonly accepted target organs.<\/jats:p>","DOI":"10.1113\/jphysiol.1979.sp012795","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:31:06Z","timestamp":1418974266000},"page":"11-18","source":"Crossref","is-referenced-by-count":14,"title":["Effects of oestrous cycle and exogenous ovarian steroids on 5\u2010hydroxytryptamine metabolism in rat lung."],"prefix":"10.1113","volume":"291","author":[{"given":"Y S","family":"Bakhle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R R","family":"Ben\u2010Harari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1979,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1979.sp012795","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1979.sp012795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T07:30:46Z","timestamp":1699169446000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1979.sp012795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,6]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,6]]}},"alternative-id":["10.1113\/jphysiol.1979.sp012795"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1979.sp012795","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,6]]}}}