{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:36:15Z","timestamp":1754109375593},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1979,6,1]],"date-time":"1979-06-01T00:00:00Z","timestamp":297043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1979,6]]},"abstract":"<jats:p>1. In nephrectomized rats, \n<jats:sc>S.C.<\/jats:sc> (0\u00b712 mg. kg body wt.<jats:sup>\u22121<\/jats:sup>) or intracerebroventricular (\n<jats:sc>I.C.V.<\/jats:sc>: 0\u00b703 mg. kg<jats:sup>\u22121<\/jats:sup>), isoprenaline failed to elicit drinking. However, when preceded (5\u201020 min) by a non\u2010dipsogenic dose of \n<jats:sc>I.V.<\/jats:sc> pig renin, \n<jats:sc>S.C.<\/jats:sc> isoprenaline induced a marked, and \n<jats:sc>I.C.V.<\/jats:sc> isoprenaline a smaller drinking response. 2 hr after \n<jats:sc>I.V.<\/jats:sc> renin, \n<jats:sc>S.C.<\/jats:sc> isoprenaline no longer caused drinking.<\/jats:p><jats:p>2. Pig renin did not enhance drinking in response to 0\u00b712 mg. kg<jats:sup>\u22121<\/jats:sup> isoprenaline \n<jats:sc>S.C.<\/jats:sc> in intact or sham\u2010operated rats.<\/jats:p><jats:p>3. Isoprenaline (0\u00b712 mg. kg body wt.<jats:sup>\u22121<\/jats:sup>, \n<jats:sc>S.C.<\/jats:sc>) caused a larger fall of blood pressure in unanaesthetized nephrectomized than in intact unanaesthetized rats, but it was not the resulting hypotension that interfered with the nephrectomized rats\u2019 ability to drink, since intact rats with similar falls in blood pressure drank avidly in response to large doses of isoprenaline.<\/jats:p><jats:p>4. Since the rate of inactivation of pig renin in nephrectomized rats was not modified by isoprenaline, drinking in nephrectomized animals in response to renin+isoprenaline was not attributable to increased plasma renin levels.<\/jats:p><jats:p>5. Since isoprenaline induces drinking in the presence of circulating renin, but in the absence of renin release from kidneys, renin plays a permissive role in isoprenaline\u2010induced drinking. Angiotensin and isoprenaline may interact at the level of intracranial receptors.<\/jats:p>","DOI":"10.1113\/jphysiol.1979.sp012800","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:31:06Z","timestamp":1418974266000},"page":"61-73","source":"Crossref","is-referenced-by-count":17,"title":["The role of circulating renin in drinking in response to isoprenaline"],"prefix":"10.1113","volume":"291","author":[{"given":"J.","family":"Atkinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010P.","family":"Kaesermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josette","family":"Lambelet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise","family":"Peters\u2010Haefeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1979,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1979.sp012800","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1979.sp012800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T07:30:43Z","timestamp":1699169443000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1979.sp012800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,6]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,6]]}},"alternative-id":["10.1113\/jphysiol.1979.sp012800"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1979.sp012800","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,6]]}}}