{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:42:12Z","timestamp":1771645332246,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1981,1,1]],"date-time":"1981-01-01T00:00:00Z","timestamp":347155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:p>1. The relation between the coupling of metabolic energy to renalp\u2010aminohippurate (PAH) accumulation and Na+\u2010K+ transport was studiedin rabbit cortical slices. 2. Cyanide (CN\u2010), 2,4\u2010dinitrophenol (DNP)and fluoride (F\u2010( at low\u2010medium concentrations, giving rise to aslight decline of tissue ATP concentration, caused a reduction o PAHaccumulation without significantly affecting intracellular Na+ and K+concentrations. However, higher levels of the metabolic inhibitorsalso resulted in considerable inhibition of active Na+\u2010K+transport. 3. The rate of carrier\u2010mediated PAH uptake was slow underanaerobic conditions, relative to that measured under aerobicconditions in Na+\u2010depleted slices. In the latter case the maximalaccumulation achieved was only 1.55 +\/\u2010 0.16. 4. The uptake rate ofPAH under anaerobic conditions was not inhibited by the absence of Na+or addition of metabolic inhibitors in the concentrations used underaerobic conditions. 5. It is concluded that although Na+ is requiredfor the attainment of high accumulation ratios of PAH, oxidativemetabolism stimulates PAH flux by a Na+\u2010independentmechanism.<\/jats:p>","DOI":"10.1113\/jphysiol.1981.sp013548","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:17:08Z","timestamp":1418973428000},"page":"273-283","source":"Crossref","is-referenced-by-count":16,"title":["An energy\u2010dependent, sodium\u2010independent component of active p\u2010aminohippurate transport in rabbit renal cortex."],"prefix":"10.1113","volume":"310","author":[{"given":"J","family":"Maxild","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J V","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M I","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1981,1]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1981.sp013548","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1981.sp013548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T02:49:45Z","timestamp":1699238985000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1981.sp013548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1113\/jphysiol.1981.sp013548"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1981.sp013548","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}