{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T23:09:13Z","timestamp":1769209753058,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1981,2,1]],"date-time":"1981-02-01T00:00:00Z","timestamp":349833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1981,2]]},"abstract":"<jats:p>1. Mechanical and intracellular electrical activities were recorded simultaneously from canine fundal and antral smooth muscle preparations.<\/jats:p><jats:p>2. Most fundal preparations displayed no spontaneous electrical or mechanical activity. The tissue had a space constant of 1\u00b75 mm and a time constant of 189 msec and showed outward rectification in response to depolarizing current.<\/jats:p><jats:p>3. Transmural nerve stimulation of fundal preparations demonstrated the presence of cholinergic excitatory and non\u2010cholinergic, non\u2010adrenergic inhibitory neural inputs to the tissue. The cholinergic nerve response consisted of a small, graded depolarization accompanied by a slow graded contraction; the inhibitory nerve response consisted of a graded hyperpolarization accompanied by a slow relaxation.<\/jats:p><jats:p>4. The excitatory fundal nerve response was abolished or greatly diminished by D<jats:sub>600<\/jats:sub> and Mn<jats:sup>2+<\/jats:sup>. D<jats:sub>600<\/jats:sub> and Mn<jats:sup>2+<\/jats:sup> also decreased basal tone. The inhibitory nerve response was unaffected by either agent.<\/jats:p><jats:p>5. The excitatory nerve response in the fundus was contrasted with the excitatory nerve response in the antrum. In the fundus, stimulation of cholinergic motor nerves produced a depolarization which always produced a contraction. In the antrum, stimulation of cholinergic motor nerves between action potentials produced graded depolarizations of antral cells; however, there were no associated contractions. Stimulation of cholinergic motor nerves during spontaneous action potentials increased the amplitude and duration of the plateau phase of the action potential; this was associated with an augmentation of the spontaneous contractions.<\/jats:p><jats:p>6. Voltage\u2014tension curves were determined for antral and fundal preparations using K<jats:sup>+<\/jats:sup> depolarization as a means of controlling membrane potential. Antral preparations displayed a voltage threshold for contraction at a membrane potential approximately 30 m V positive to the resting potential. In cntrast, fundal resting potentials were at or more positive than their voltage thresholds.<\/jats:p><jats:p>7. These differences in electromechanical coupling provide an explanation for the marked differences in the responses of fundal and antral smooth muscles to nerve stimulation and account for their physiologic function <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1113\/jphysiol.1981.sp013599","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:15:37Z","timestamp":1418973337000},"page":"475-488","source":"Crossref","is-referenced-by-count":55,"title":["The electrical basis for contraction and relaxation in canine fundal smooth muscle"],"prefix":"10.1113","volume":"311","author":[{"given":"Kathleen G.","family":"Morgan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. C.","family":"Muir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Szurszewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1981,2]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1981.sp013599","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1981.sp013599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T05:17:30Z","timestamp":1699247850000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1981.sp013599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,2]]}},"alternative-id":["10.1113\/jphysiol.1981.sp013599"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1981.sp013599","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,2]]}}}