{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:30:45Z","timestamp":1771633845427,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1981,12,1]],"date-time":"1981-12-01T00:00:00Z","timestamp":376012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1981,12]]},"abstract":"<jats:p>1. The rate of acetylcholine (ACh)\u2010induced fluid secretion was measured from the main secretory duct of rabbit lacrimal glands perfused in vivo with Krebs Henseleit bicarbonate solutions. 2. Perfusion with ouabain (10(\u20105) M) decreased the rate of lacrimal gland fluid secretion to 23% of the control value. 3. Perfusion with furosemide (10(\u20104) and 10(\u20103) M), which has been shown to inhibit the coupled transport of Na+ and Cl\u2010, reversibly decreased the rate of secretion to 43 and 33% of the control value respectively. 4. (Na+ + K+)\u2010activated ATPase was localized in slices of rabbit lacrimal gland using autoradiography with [3H]ouabain. 5. A high density of [3H]ouabain binding sites was present on ductal cells, whereas a very low density was found on acinar cells. For both types of cells the [3H]ouabain binding sites were located on the basolateral plasma membranes. 6. It is concluded that ACh\u2010induced secretion of electrolytes and water is dependent upon (Na+ + K+)\u2010activated ATPase. In addition, coupled transport of Na+ and Cl\u2010 appears to be involved in secretion. 7. Basolateral location of the (Na+ + K+)\u2010activated ATPase implies that it plays an indirect role in electrolyte and water secretion. A possible role may be to energize a secondary active transport of Cl\u2010 that is mediated by a NaCl cotransport system.<\/jats:p>","DOI":"10.1113\/jphysiol.1981.sp014002","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:09:00Z","timestamp":1418972940000},"page":"557-569","source":"Crossref","is-referenced-by-count":59,"title":["Lacrimal gland electrolyte and water secretion in the rabbit: localization and role of (Na+ + K+)\u2010activated ATPase."],"prefix":"10.1113","volume":"321","author":[{"given":"D A","family":"Dartt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1981,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1981.sp014002","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1981.sp014002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T05:00:47Z","timestamp":1699246847000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1981.sp014002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,12]]}},"alternative-id":["10.1113\/jphysiol.1981.sp014002"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1981.sp014002","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,12]]}}}