{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:47:57Z","timestamp":1762098477862},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1982,6,1]],"date-time":"1982-06-01T00:00:00Z","timestamp":391737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1982,6]]},"abstract":"<jats:p>1. Extracellular recordings of the responses of single caudal trigeminal nucleus neurones to non\u2010noxious and noxious facial stimuli and to ionophoretically applied L\u2010glutamate, L\u2010aspartate and acetylcholine were made in urethane anaesthetized rats. 2. Neurones excited by non\u2010noxious mechanical stimuli were located primarily in the magnocellular part of nucleus caudalis, whereas neurones excited by both noxious and non\u2010noxious stimuli were located either ventromedially to the magnocellular part of nucleus caudalis or superficially to the substantia gelatinosa. 3. Both L\u2010aspartate and L\u2010glutamate were found to excite all neurones tested in nucleus caudalis. In contrast, however, acetylcholine was found to excite only 31% of the neurones tested. 4. Responses of nucleus caudalis neurones to non\u2010noxious sensory stimulation were not antagonized by the excitatory amino acid antagonist D\u2010alpha\u2010aminoadipate, but were antagonized by cis\u20102, 3\u2010piperidine dicarboxylate and gamma\u2010D\u2010glutamylglycine, two excitatory amino acid antagonists with a broader spectrum of action. 5. It is concluded that the chemical synaptic transmitter of non\u2010nociceptive mechanoreceptive primary afferent fibres to nucleus caudalis may be a ligand for an excitatory amino acid receptor other than a D\u2010alpha\u2010aminoadipate\u2010sensitive receptor. The synaptic receptor may thus be of the kainate or quisqualate type, and the transmitter possibly L\u2010glutamate, L\u2010aspartate or an as yet unidentified substance.<\/jats:p>","DOI":"10.1113\/jphysiol.1982.sp014220","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:03:24Z","timestamp":1418972604000},"page":"65-78","source":"Crossref","is-referenced-by-count":38,"title":["An ionophoretic study of the responses of rat caudal trigeminal nucleus neurones to non\u2010noxious mechanical sensory stimuli."],"prefix":"10.1113","volume":"327","author":[{"given":"R G","family":"Hill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T E","family":"Salt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1982,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1982.sp014220","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1982.sp014220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T17:43:24Z","timestamp":1699206204000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1982.sp014220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,6]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,6]]}},"alternative-id":["10.1113\/jphysiol.1982.sp014220"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1982.sp014220","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,6]]}}}