{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T21:35:53Z","timestamp":1774474553228,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1982,11,1]],"date-time":"1982-11-01T00:00:00Z","timestamp":404956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1982,11]]},"abstract":"<jats:p>1. Intracellular electrical recording techniques were used to study the ionic mechanisms of cholinergic synaptic transmission in cat vesical pelvic ganglia (v.p.g.). 2. Orthodromic nerve stimulation as well as ionophoretic application of acetylcholine (ACh) resulted in, first, a fast excitatory post\u2010synaptic potential (f.e.p.s.p.) and secondly, a slow inhibitory post\u2010synaptic potential (s.i.p.s.p). These distinct post\u2010synaptic responses were direct actions of ACh and not mediated through an interneurone. In addition, a slow excitatory post\u2010synaptic potential (s.e.p.s.p.) was observed in 44% of the cells. 3. The f.e.p.s.p., mediated via nicotinic receptors, had a reversal potential of \u201010 mV and resembled the conventional rapid depolarization in other ganglia. The s.i.p.s.p., mediated by muscarinic receptors, had a reversal potential of about \u2010100 mV and resulted from an increase in potassium conductance. 4. The slow muscarinic hyperpolarization could be observed in the absence of antagonists and it was elicited at stimulus frequencies in the physiological range (2\u201010 Hz). the s.i.p.s.p. induced orthodromically or ionophoretically inhibited firing in spontaneously active neurones. These observations suggest that the muscarinic hyperpolarization may occur under physiological conditions and has sufficient magnitude to be inhibitory to neuronal activity.<\/jats:p>","DOI":"10.1113\/jphysiol.1982.sp014425","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:02:05Z","timestamp":1418972525000},"page":"473-486","source":"Crossref","is-referenced-by-count":62,"title":["Cholinergic transmission in cat parasympathetic ganglia."],"prefix":"10.1113","volume":"332","author":[{"given":"J P","family":"Gallagher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W H","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Shinnick\u2010Gallagher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1982,11]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1982.sp014425","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1982.sp014425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T23:56:19Z","timestamp":1699228579000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1982.sp014425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,11]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,11]]}},"alternative-id":["10.1113\/jphysiol.1982.sp014425"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1982.sp014425","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,11]]}}}