{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T22:44:28Z","timestamp":1769381068688,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1983,6,1]],"date-time":"1983-06-01T00:00:00Z","timestamp":423273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:p>We studied the effect of neurotoxin (JSTX) separated from spider venom on the lobster neuromuscular junction. JSTX selectively suppressed excitatory post\u2010synaptic potentials (e.p.s.p.s) without affecting the inhibitory post\u2010synaptic potentials (i.p.s.p.s). The effect of JSTX was dose\u2010dependent. The threshold dose for suppressing e.p.s.p.s corresponded to a small fraction of the toxin amount in a venom gland. At high concentration, JSTX irreversibly blocked e.p.s.p.s. The reduction in amplitude of extracellularly recorded e.p.s.p.s after JSTX application followed an exponential time course. The rate of suppression increased proportionally with the toxin concentration. JSTX blocked the glutamate potential in the post\u2010synaptic membrane but it failed to affect the aspartate\u2010induced depolarization. Kainic acid potentiated the glutamate\u2010induced depolarization but it was without effect in the presence of JSTX. Depolarization produced by quisqualic acid is suppressed by the toxin. Our results suggest that the spider venom contains specific blockers of glutamate receptors in crustacean neuromuscular junctions.<\/jats:p>","DOI":"10.1113\/jphysiol.1983.sp014714","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:57:52Z","timestamp":1418972272000},"page":"243-252","source":"Crossref","is-referenced-by-count":117,"title":["Effects of a spider toxin on the glutaminergic synapse of lobster muscle."],"prefix":"10.1113","volume":"339","author":[{"given":"T","family":"Abe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1983,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1983.sp014714","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1983.sp014714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T12:22:59Z","timestamp":1697718179000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1983.sp014714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,6]]}},"alternative-id":["10.1113\/jphysiol.1983.sp014714"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1983.sp014714","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6]]}}}