{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T23:48:53Z","timestamp":1773532133941,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1983,6,1]],"date-time":"1983-06-01T00:00:00Z","timestamp":423273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:p>Acetylcholine\u2010induced single\u2010channel currents were measured in the presence of the lignocaine derivative QX222. Unit responses appeared as bursts of short current pulses as a result of the fast blocking action of the drug (QX222). The amplitude of the individual current pulses was not changed by the presence of the drug up to a concentration of 250 microM. The time integral of current during a burst, which for a sequential blocking model should be independent of drug concentration, decreased at concentrations of QX222 higher than 40 microM. The distribution of gap times within a burst could not be fitted by a single exponential for high concentrations of QX222. It is concluded that the simple sequential model of channel blockade does not apply for concentrations of QX222 higher than 40 microM.<\/jats:p>","DOI":"10.1113\/jphysiol.1983.sp014741","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:57:52Z","timestamp":1418972272000},"page":"663-678","source":"Crossref","is-referenced-by-count":148,"title":["The charge carried by single\u2010channel currents of rat cultured muscle cells in the presence of local anaesthetics."],"prefix":"10.1113","volume":"339","author":[{"given":"E","family":"Neher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1983,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1983.sp014741","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1983.sp014741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T12:22:28Z","timestamp":1697718148000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1983.sp014741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,6]]}},"alternative-id":["10.1113\/jphysiol.1983.sp014741"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1983.sp014741","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6]]}}}