{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T20:27:46Z","timestamp":1702240066930},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1983,8,1]],"date-time":"1983-08-01T00:00:00Z","timestamp":428544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1983,8]]},"abstract":"<jats:p>The actions of d\u2010tubocurarine (d\u2010TC) and local anaesthetics on the L\u2010glutamate activated channel at the voltage\u2010clamped crayfish neuromuscular junction were studied. The effect of d\u2010TC and local anaesthetics on the dose\u2010response relationship between ionophoretically applied L\u2010glutamate and synaptic current suggested that both acted as non\u2010competitive inhibitors. The amount of inhibition was voltage dependent, and increased as the membrane potential was hyperpolarized. This voltage\u2010dependent block was also manifest in a flattening of the I\u2010V relationship between L\u2010glutamate induced current and membrane potential in the presence of d\u2010TC. However, the reversal potential for the L\u2010glutamate activated channel was not affected; it was about +7 mV in both the presence and absence of d\u2010TC. The neurally evoked excitatory post\u2010synaptic current (e.p.s.c.) was depressed in the presence of these drugs and this effect was also voltage dependent. The time course of the e.p.s.c. was affected, but less so than expected if the L\u2010glutamate activated channel were identical to the channel opened by acetylcholine at the vertebrate neuromuscular junction. Possible reasons for this discrepancy are discussed.<\/jats:p>","DOI":"10.1113\/jphysiol.1983.sp014796","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:55:28Z","timestamp":1418972128000},"page":"127-138","source":"Crossref","is-referenced-by-count":4,"title":["Voltage\u2010dependent drug blockade of L\u2010glutamate activated channels of the crayfish."],"prefix":"10.1113","volume":"341","author":[{"given":"M S","family":"Dekin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1983,8]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1983.sp014796","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1983.sp014796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T06:09:31Z","timestamp":1697782171000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1983.sp014796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,8]]}},"alternative-id":["10.1113\/jphysiol.1983.sp014796"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1983.sp014796","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,8]]}}}