{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:10:47Z","timestamp":1791245447732,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1983,10,1]],"date-time":"1983-10-01T00:00:00Z","timestamp":433814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:p>Ventilation was studied during wakefulness and sleep in six healthy humans in normoxia (mean barometric pressure (PB) = 740 torr), and in hypobaric hypoxia (PB = 455 torr). Hypoxia caused hyperventilation and hypocapnic alkalosis (delta Pa,CO2 = \u20107 torr) during wakefulness and in all sleep states. Periodic breathing was the predominant pattern of breathing in all stages of non\u2010rapid eye movement (non\u2010r.e.m.) sleep in hypoxia, but was rarely observed during wakefulness or r.e.m. sleep. Periodic breathing was composed of repetitive oscillations of reproducible cycle length characterized by clusters of breaths with augmented inspiratory effort (VT\/TI) and highly variable distribution of breath\u2010to\u2010breath minute ventilation (VE) and tidal volume (VT), which alternated regularly with prolongations of the expiratory pause of the last breath of each cluster (apnea duration = 5\u201018 sec). Hypoxia\u2010induced periodic breathing was eliminated by: (a) acute restoration of normoxia coincident with a 3\u20106 torr increase in Pa,CO2; and (b) augmented FI,CO2 (at constant arterial oxygen saturation) which rapidly and reversibly eliminated apneas and stabilized breathing pattern with a less than 2 torr increase in Pa,CO2. If hypocapnia was prevented (by augmented FI,CO2) during acute induction of hypoxia in non\u2010r.e.m. sleep, periodic breathing was also prevented. We propose that the genesis of hypoxia\u2010induced periodic breathing requires the combination of hypoxia and hypocapnia. Periodicity results from oscillations in CO2 about a CO2\u2010apnea threshold whose functional expression is critically linked to sleep state.<\/jats:p>","DOI":"10.1113\/jphysiol.1983.sp014906","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T01:54:23Z","timestamp":1418954063000},"page":"507-526","source":"Crossref","is-referenced-by-count":229,"title":["Mechanisms of hypoxia\u2010induced periodic breathing during sleep in humans."],"prefix":"10.1113","volume":"343","author":[{"given":"A","family":"Berssenbrugge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Iber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Skatrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1983,10]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1983.sp014906","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1983.sp014906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T04:40:25Z","timestamp":1697776825000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1983.sp014906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,10]]}},"alternative-id":["10.1113\/jphysiol.1983.sp014906"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1983.sp014906","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,10]]}}}