{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:30:44Z","timestamp":1771633844314,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1984,4,1]],"date-time":"1984-04-01T00:00:00Z","timestamp":449625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:p>The role played by anions in salivary secretion has been studied in experiments on the isolated, perfused mandibular gland of the rabbit, in which perfusate Cl\u2010 and\/or HCO3\u2010 were replaced by other anions. Replacement of Cl\u2010 with Br\u2010 had no significant effect on salivary secretion rate, but replacement with the other anions tested caused secretory rate to fall, by 38% (I\u2010), 50% (NO3\u2010), 61% (isethionate, ise \u2010), and 66% ( CH3SO4 \u2010), respectively. Replacement of perfusate Cl\u2010 with ise \u2010 or CH3SO4 \u2010 caused the salivary HCO3\u2010 concentration to rise up to 4\u2010fold. Replacement with Br\u2010 or I\u2010 seemed to have little effect on salivary HCO3\u2010 concentration but, in contrast to ise \u2010, Br\u2010 and I\u2010 entered the saliva in concentrations comparable to those of Cl\u2010 during control perfusion. In glands perfused with HCO3\u2010 and ise \u2010, the addition of methazolamide, an inhibitor of carbonic anhydrase, caused a further 60% drop in secretory rate, but the saliva remained rich in HCO3\u2010. Replacement of perfusate HCO3\u2010 with Cl\u2010 or ise \u2010 had no effect on salivary secretion or composition. Replacement of both HCO3\u2010 and Cl\u2010 in the perfusate with ise \u2010 reduced salivary secretion to less than 2% of control levels. In control glands (i.e. perfused with both HCO3\u2010 and Cl\u2010), administration of furosemide, an inhibitor of Na+\/Cl\u2010 co\u2010transport, reduced the secretion rate and increased salivary HCO3\u2010 in a manner indistinguishable from that seen when perfusate Cl\u2010 was replaced with ise \u2010. In control perfused glands, administration of SITS (4\u2010acetamido\u20104'\u2010 isothio cyano\u20102,2'\u2010disulphonic acid stilbene), an inhibitor of Cl\u2010\/HCO3\u2010 antiports , did not cause any change in salivary HCO3\u2010 concentration. Unexpectedly, it induced a significant increase in salivary secretory rate. The results show that salivary secretion depends on two independent transport systems. One is a Cl\u2010 \u2010dependent, furosemide\u2010sensitive system, probably a Na+\/Cl\u2010 symport. The other is an HCO3\u2010 \u2010dependent, methazolamide\u2010sensitive system, and is probably an Na+\/H+ antiport.<\/jats:p>","DOI":"10.1113\/jphysiol.1984.sp015177","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:50:39Z","timestamp":1418971839000},"page":"619-630","source":"Crossref","is-referenced-by-count":68,"title":["The anionic basis of fluid secretion by the rabbit mandibular salivary gland."],"prefix":"10.1113","volume":"349","author":[{"given":"R M","family":"Case","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Novak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1984,4]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1984.sp015177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1984.sp015177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:01:29Z","timestamp":1697760089000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1984.sp015177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,4]]}},"alternative-id":["10.1113\/jphysiol.1984.sp015177"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1984.sp015177","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,4]]}}}