{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:06:00Z","timestamp":1791216360122,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1984,9,1]],"date-time":"1984-09-01T00:00:00Z","timestamp":462844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1984,9]]},"abstract":"<jats:p>Spontaneous activity in bladder muscle strips from man, pig and rabbit has been compared using an in vitro superfusion technique. Field stimulation was used to study nerve\u2010mediated activity. Bladder muscle strips from all areas of the rabbit bladder displayed rhythmic spontaneous activity. Spontaneous activity was regularly present in strips from the trigone region in man and pig, but was present in only 18 and 19% respectively of strips from the dome of the bladder. Strength\u2010duration curves in the presence of tetrodotoxin (10(\u20107) g\/ml) were constructed. The 'chronaxie' of the muscle was found to be considerably shorter than that of other smooth muscles, ranging from 6.1 ms in the rabbit to 12.9 ms in man. Frequency\u2010response curves were constructed using trains of stimuli. The responses were not antagonized by hexamethonium (10(\u20104) M), but were markedly inhibited by tetrodotoxin (10(\u20107) g\/ml), indicating that the responses were mediated by excitation of post\u2010ganglionic nerves. Physostigmine (10(\u20107)\u20105 X 10(\u20106) M) produced a dose\u2010related increase in the contractile response to field stimulation in all three species. Atropine (10(\u20108)\u201010(\u20106) M) produced an inhibition of the contractile response, but the maximum degree of inhibition differed considerably between the species. In the rabbit, 58% of the control response was attained, whilst in the pig this was only 22%. Atropine completely abolished nerve\u2010mediated contractions in human bladder muscle. Phentolmaine (10(\u20107)\u20102.5 X 10(\u20107) M) had no significant effect on the frequency\u2010response curve in any of the three species, and did not depress the atropine\u2010resistant component in rabbit and pig. It is concluded that nerve\u2010mediated activity in human bladder muscle is exclusively cholinergic, in contrast to most other mammals studied in which there is a significant non\u2010cholinergic component. The finding of a shorter chronaxie in bladder muscle than in other smooth muscles suggests important differences in its physiological properties that merit further investigation.<\/jats:p>","DOI":"10.1113\/jphysiol.1984.sp015386","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:48:40Z","timestamp":1418971720000},"page":"431-443","source":"Crossref","is-referenced-by-count":302,"title":["A comparison of spontaneous and nerve\u2010mediated activity in bladder muscle from man, pig and rabbit."],"prefix":"10.1113","volume":"354","author":[{"given":"G N","family":"Sibley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1984,9]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1984.sp015386","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1984.sp015386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T21:57:36Z","timestamp":1697752656000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1984.sp015386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,9]]}},"alternative-id":["10.1113\/jphysiol.1984.sp015386"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1984.sp015386","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,9]]}}}