{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:58:09Z","timestamp":1762113489547},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1985,2,1]],"date-time":"1985-02-01T00:00:00Z","timestamp":476064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1985,2]]},"abstract":"<jats:p>Brief tetanic stimulation of the preganglionic nerve induced a persistent potentiation of nicotinic synaptic transmission in the rat superior cervical sympathetic ganglion. Quantitative measurements of the post\u2010tetanic increase in synaptic efficacy revealed two distinct time courses. The early, rapidly decaying component, termed post\u2010tetanic potentiation (p.t.p.), had a decay time constant of 2\u20103 min, as reported elsewhere. The duration of the more persistent component, called long\u2010term potentiation (l.t.p.), was extremely temperature dependent, lasting much longer at 32 degrees C than at 22 degrees C. In half of the experiments performed at 32 degrees C, l.t.p. showed no detectable decay over the course of 1 h or more after a brief tetanic stimulation. Other experiments were conducted at 22 degrees C. The induction of l.t.p. was dependent on the extracellular [Ca2+]. Transient elevation of the extracellular [K+] also produced a long\u2010term enhancement of synaptic efficacy, and this effect was also Ca2+ dependent. The tetani that were effective in inducing l.t.p. (5\u201020 Hz for 5\u201020 s) were well within the physiological range of preganglionic activity. The magnitude and time course were related to frequency and duration of stimulation. The occurrence of l.t.p. was restricted to those preganglionic fibres that were tetanically stimulated. This lack of heterosynaptic or generalized effects was demonstrated by splitting the preganglionic nerve into two branches that could be independently tested and conditioned. Physiological activation of muscarinic or nicotinic receptors apparently does not play an essential role in causing ganglionic l.t.p., which is expressed as an enhancement of nicotinic transmission. A muscarinic antagonist (2 microM\u2010atropine) did not block l.t.p. Preganglionic stimulation induced l.t.p. even when a high concentration of a nicotinic antagonist (3 mM\u2010hexamethonium) was present during the tetanic stimulation. Furthermore, bath application of a cholinergic agonist (100\u20101000 microM\u2010carbachol) could not substitute for tetanic stimulation in provoking l.t.p. Activation of adrenergic receptors also appeared not to play an essential role. Neither a beta\u2010adrenergic antagonist (10 microM\u2010sotolol or 1 microM\u2010propranolol) nor an alpha\u2010adrenergic antagonist (1 microM\u2010phentolamine) had any significant effect on the magnitude or duration of l.t.p. The results indicate that ganglionic l.t.p. is a Ca2+\u2010 and temperature\u2010dependent process that can be created independently of the activation of nicotinic, muscarinic or adrenergic receptors.<\/jats:p>","DOI":"10.1113\/jphysiol.1985.sp015599","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:47:00Z","timestamp":1418971620000},"page":"503-521","source":"Crossref","is-referenced-by-count":72,"title":["Neurophysiology and pharmacology of long\u2010term potentiation in the rat sympathetic ganglion."],"prefix":"10.1113","volume":"359","author":[{"given":"C A","family":"Briggs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T H","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"McAfee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1985,2]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1985.sp015599","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1985.sp015599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T15:54:18Z","timestamp":1697817258000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1985.sp015599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,2]]}},"alternative-id":["10.1113\/jphysiol.1985.sp015599"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1985.sp015599","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,2]]}}}