{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:19:36Z","timestamp":1771640376460,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1985,6,1]],"date-time":"1985-06-01T00:00:00Z","timestamp":486432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1985,6]]},"abstract":"<jats:p>Active transport of amino acids and the sugar, alpha\u2010methyl\u2010D\u2010glucoside (alpha\u2010MG) caused an increase in the rate of K efflux from isolated rabbit enterocytes. These effects were inhibited by apamin (5 X 10(\u20107) M), quinidine (10(\u20103) M), Ba (5 X 10(\u20103) M) and trifluoperazine (5 X 10(\u20105) M) but not by the loop diuretic furosemide (10(\u20104) M). None of these drugs affected the basal rate of K efflux. The stimulatory effects of amino acids or alpha\u2010MG on K efflux are too great to be explained in terms of an increase in the electrical driving force across the plasma membrane of these cells and a change in membrane permeability is envisaged. An apparent Ca\u2010dependent K permeability in isolated enterocytes can be demonstrated using the Ca ionophore A23187. The effect of the ionophore on K efflux is abolished by apamin or Ba. It is proposed that Ca\u2010dependent K channels mediate the sugar and amino acid induced increases of K efflux. Under control conditions there is a decrease in intracellular K concentration during accumulation of alanine or alpha\u2010MG. Ba by itself does not alter K concentration but it did produce a marked increase when used in conjunction with alanine or alpha\u2010MG. The accumulation of alpha\u2010MG was inhibited in the presence of Ba. This is consistent with an interference with the driving force for sugar accumulation. It is suggested that the increase in K permeability described has a role in both maintaining ion homoeostasis during Na\u2010coupled transport and contributing to the driving force for sugar and amino acid absorption.<\/jats:p>","DOI":"10.1113\/jphysiol.1985.sp015709","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:46:17Z","timestamp":1418971577000},"page":"271-285","source":"Crossref","is-referenced-by-count":39,"title":["Potassium movements associated with amino acid and sugar transport in enterocytes isolated from rabbit jejunum."],"prefix":"10.1113","volume":"363","author":[{"given":"P D","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F V","family":"Sep\u00falveda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1985,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1985.sp015709","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1985.sp015709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T21:46:47Z","timestamp":1697838407000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1985.sp015709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,6]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,6]]}},"alternative-id":["10.1113\/jphysiol.1985.sp015709"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1985.sp015709","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,6]]}}}