{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:19:44Z","timestamp":1771640384410,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1985,7,1]],"date-time":"1985-07-01T00:00:00Z","timestamp":489024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1985,7]]},"abstract":"<jats:p>The effects of electrical field stimulation and tetrodotoxin on the mucosal secretory response were compared in guinea\u2010pig ileal mucosa with and without the submucosal plexus. Short\u2010circuit currents and transmural electrical potential differences were similar in ganglionated and aganglionated tissues. Total tissue conductance was greater after removal of the submucosal ganglia. Electrical field stimulation evoked a tetrodotoxin\u2010sensitive increase in short\u2010circuit current in ganglionated tissues, and little or no response in aganglionated tissues. Both ganglionated and aganglionated tissues responded similarly to carbachol, vasoactive intestinal polypeptide, scorpion venom and alanine. These results suggest that electrical field stimulation of guinea\u2010pig ileum evokes an increase in short\u2010circuit current that reflects chloride secretion by exciting ganglion cell bodies whose axons project to the transporting cells and\/or endocrine cells. Direct electrical activation of enteroendocrine cells is not a factor in the stimulus\u2010evoked secretory response.<\/jats:p>","DOI":"10.1113\/jphysiol.1985.sp015730","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:46:15Z","timestamp":1418971575000},"page":"69-79","source":"Crossref","is-referenced-by-count":38,"title":["Mucosal responses evoked by stimulation of ganglion cell somas in the submucosal plexus of the guinea\u2010pig ileum."],"prefix":"10.1113","volume":"364","author":[{"given":"H V","family":"Carey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Zafirova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1985,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1985.sp015730","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1985.sp015730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T21:38:12Z","timestamp":1697924292000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1985.sp015730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,7]]}},"alternative-id":["10.1113\/jphysiol.1985.sp015730"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1985.sp015730","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,7]]}}}