{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:24:34Z","timestamp":1756895074562},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1985,10,1]],"date-time":"1985-10-01T00:00:00Z","timestamp":496972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1985,10]]},"abstract":"<jats:p>The cardiovascular and neuroendocrine effects of a selective kappa\u2010opiate receptor agonist (U50488H) microinjected into the nucleus tractus solitarii have been investigated in urethane\u2010anaesthetized rats. Comparative experiments were conducted using 8\u2010arginine vasopressin (AVP)\u2010deficient Brattleboro rats and an opiate agonist selective for delta receptors. Unilateral injection of U50488H elicited a significant dose\u2010dependent increase in mean arterial pressure and a small decrease in heart rate in Sprague\u2010Dawley rats. The pressor effect was blocked preferentially by the relatively selective kappa\u2010receptor antagonist MR2266BS compared to naloxone. Bilateral injections of U50488H elicited a relatively greater increase in mean arterial pressure than unilateral injections and a significant decrease in heart rate. U50488H did not elicit a pressor effect in Brattleboro rats, whereas a marked response (associated with a significant increase in AVP secretion) was found in parent strain Long\u2010Evans rats. In contrast, no such differential effects in the response of Brattleboro and Long\u2010Evans rats were observed in parallel experiments using equimolar doses of the selective delta\u2010opiate agonist Tyr\u2010D\u2010Ser\u2010Gly\u2010Phe\u2010Leu\u2010Thr which elicited a transient pressor response. An antagonist [1\u2010(beta\u2010mercapto\u2010beta, beta\u2010cyclopentamethylene\u2010propionic acid)2\u2010(0\u2010methyl) tyrosine] arginine vasopressin (1,d(CH2)5Tyr(ME)AVP) specific for the vasopressor action of AVP blocked the U50488H\u2010induced pressor response in a dose\u2010dependent manner when administered intravenously 10 min prior to the kappa agonist, but did not significantly attenuate the response to the delta agonist. Conversely, the U50488H\u2010induced response was not modified by pre\u2010treatment with phenoxybenzamine whereas the delta\u2010agonist pressor response was completely blocked by it. The results provide evidence for specific kappa\u2010opiate cardiovascular and neuroendocrine responses in the nucleus tractus solitarii and suggest that a kappa\u2010receptor mechanism, possibly involving a peptide of the dynorphin group as the endogenous ligand, may operate in the central control of blood pressure and AVP secretion.<\/jats:p>","DOI":"10.1113\/jphysiol.1985.sp015829","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:45:38Z","timestamp":1418971538000},"page":"363-375","source":"Crossref","is-referenced-by-count":28,"title":["Selective cardiovascular and neuroendocrine effects of a kappa\u2010opioid agonist in the nucleus tractus solitarii of rats."],"prefix":"10.1113","volume":"367","author":[{"given":"D A","family":"Carter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L","family":"Lightman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1985,10]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1985.sp015829","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1985.sp015829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T17:47:16Z","timestamp":1697824036000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1985.sp015829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,10]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,10]]}},"alternative-id":["10.1113\/jphysiol.1985.sp015829"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1985.sp015829","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,10]]}}}