{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:25:06Z","timestamp":1773296706473,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1986,1,1]],"date-time":"1986-01-01T00:00:00Z","timestamp":504921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:p>Adenosine and several of its analogues produced a concentration\u2010dependent shortening of calcium\u2010dependent action potential (c.a.p.) duration of mouse dorsal root ganglion (d.r.g.) neurones in dissociated cell culture. The following rank order of potency was obtained: N6\u2010(L\u2010phenylisopropyl)adenosine greater than N6\u2010(D\u2010phenylisopropyl)adenosine greater than N6\u2010cyclohexyladenosine greater than 2\u2010chloroadenosine much greater than 1\u2010methylisoguanosine greater than adenosine. Effects of adenosine agonists on c.a.p. duration were blocked by methylxanthine adenosine antagonists. Adenosine monophosphate (AMP) and cyclic AMP shortened c.a.p.s in d.r.g. neurones, while ATP also depolarized cells. Voltage\u2010clamp analysis revealed that the effect arose from reduction of a voltage\u2010dependent calcium conductance. Adenosine agonists reduced depolarization\u2010evoked inward currents but did not alter membrane conductance following blockade of calcium channels by cadmium. Additionally, adenosine reduced the instantaneous current\u2010voltage slope (chord conductance) during step commands that produced maximal activation of voltage\u2010dependent calcium conductance. If effects of adenosine on neuronal somata and synaptic terminals are similar, adenosine agonists may inhibit neurotransmitter release in the central nervous system by inhibiting a voltage\u2010dependent calcium conductance. Since effects of adenosine agonists did not correspond with their relative potencies as modulators of adenylate cyclase activity or inhibitors of neurotransmitter release in peripheral tissues, a novel adenosine receptor may be involved in regulation of this conductance.<\/jats:p>","DOI":"10.1113\/jphysiol.1986.sp015923","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:44:55Z","timestamp":1418971495000},"page":"75-90","source":"Crossref","is-referenced-by-count":142,"title":["Adenosine agonists reduce voltage\u2010dependent calcium conductance of mouse sensory neurones in cell culture."],"prefix":"10.1113","volume":"370","author":[{"given":"R L","family":"MacDonald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Skerritt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Werz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1986,1]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1986.sp015923","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1986.sp015923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T10:12:44Z","timestamp":1697883164000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1986.sp015923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1113\/jphysiol.1986.sp015923"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1986.sp015923","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}