{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T09:12:21Z","timestamp":1697965941466},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1986,3,1]],"date-time":"1986-03-01T00:00:00Z","timestamp":510019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:p>Anuran membrane studies suggest that the calcium\u2010binding protein calmodulin is necessary for arginine vasopressin (AVP) to exert a hydro\u2010osmotic effect. We therefore examined the effect of trifluoperazine and N\u2010(6\u2010aminohexyl)\u20105\u2010chloro\u20101\u2010naphtholene sulphonamide (W\u20107), chemically dissimilar calmodulin inhibitors, on hydraulic conductivity (Lp) response to AVP in rabbit cortical collecting tubules perfused in vitro. Trifluoperazine but not W\u20107 increased basal Lp in rabbit cortical collecting tubules. When cortical collecting tubules were pre\u2010treated with either trifluoperazine or W\u20107, the effect of AVP to increase Lp was significantly inhibited. To determine the site of this inhibition, Lp responses to exogenous cyclic adenosine 3',5'\u2010phosphate (AMP) were studied. Both trifluoperazine and W\u20107 pretreatment significantly inhibited the effect of a cyclic AMP analogue to increase rabbit cortical collecting tubule Lp. These results suggest that calmodulin may be an important mediator of the hydro\u2010osmotic response to AVP in the mammalian cortical collecting tube by acting at a site or sites distal to cyclic AMP formation.<\/jats:p>","DOI":"10.1113\/jphysiol.1986.sp015995","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:44:25Z","timestamp":1418971465000},"page":"41-50","source":"Crossref","is-referenced-by-count":6,"title":["Effect of trifluoperazine on rabbit cortical collecting tubular response to vasopressin."],"prefix":"10.1113","volume":"372","author":[{"given":"M A","family":"Dillingham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B S","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J K","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P D","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1986,3]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1986.sp015995","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1986.sp015995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T23:02:55Z","timestamp":1697929375000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1986.sp015995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,3]]}},"alternative-id":["10.1113\/jphysiol.1986.sp015995"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1986.sp015995","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,3]]}}}