{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:55:46Z","timestamp":1771628146678,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1987,11,1]],"date-time":"1987-11-01T00:00:00Z","timestamp":562723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:p>1. Dogs were anaesthetized with chloralose and artificially ventilated. The carotid chemoreceptors were stimulated by changing the perfusion of vascularly isolated carotid sinus regions from arterial to venous blood. The mean carotid sinus pressure and the mean arterial blood pressure were held constant at 124 +\/\u2010 3 and 122 +\/\u2010 3 mmHg, respectively. Both vagosympathetic trunks were sectioned in the neck and propranolol (17 micrograms kg\u20101 min\u20101 I.V.) and gallamine triethiodide (0.2\u20102.0 mg kg\u20101 30 min\u20101 I.V.) were infused. Renal blood flow was measured by an electromagnetic flow probe, glomerular filtration rate by creatinine clearance, sodium excretion by flame photometry and solute excretion by osmometry. 2. In sixteen tests in thirteen dogs perfusion of the carotid sinus regions with venous blood resulted in significant decreases in renal blood flow from 271 +\/\u2010 24 to 198 +\/\u2010 21 ml min\u20101 100 g\u20101 renal mass; glomerular filtration rate from 41.0 +\/\u2010 4.8 to 22.1 +\/\u2010 3.1 ml min\u20101 100 g\u20101; filtration fraction from 0.25 +\/\u2010 0.02 to 0.19 +\/\u2010 0.02; urine flow from 0.48 +\/\u2010 1.0 to 0.21 +\/\u2010 0.03 ml min\u20101 100 g\u20101; sodium excretion from 18.1 +\/\u2010 4.1 to 12.9 +\/\u2010 4.2 mumol min\u20101 100 g\u20101; and osmolar excretion 327 +\/\u2010 42 to 171 +\/\u2010 26 mu osmol min\u20101 100 g\u20101. The right atrial pressure did not change significantly from 4.6 +\/\u2010 1.2 cmH2O. 3. In seven dogs, tying renal sympathetic nerves abolished all the responses except that of sodium excretion which was now reversed; sodium excretion increased from 68 +\/\u2010 19 to 116 +\/\u2010 38 mumol min\u20101 100 g\u20101 without significant change in right atrial pressure from 7.4 +\/\u2010 1.9 cmH2O. Crushing the carotid bodies, however, abolished all the responses. 4. The results show that carotid chemoreceptor stimulation can cause significant reflex effects on renal haemodynamics and function which are mediated via renal sympathetic nerves. They also show that the chemoreceptor stimulation can cause natriuresis in the absence of haemodynamic changes, in the denervated kidney, presumably via a humoral factor.<\/jats:p>","DOI":"10.1113\/jphysiol.1987.sp016790","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:39:20Z","timestamp":1418971160000},"page":"451-462","source":"Crossref","is-referenced-by-count":23,"title":["The effects of stimulating carotid chemoreceptors on renal haemodynamics and function in dogs."],"prefix":"10.1113","volume":"392","author":[{"given":"F","family":"Karim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Poucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Summerill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1987,11]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1987.sp016790","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1987.sp016790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T04:20:55Z","timestamp":1697862055000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1987.sp016790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,11]]}},"alternative-id":["10.1113\/jphysiol.1987.sp016790"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1987.sp016790","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11]]}}}