{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T20:46:26Z","timestamp":1700081186106},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1987,12,1]],"date-time":"1987-12-01T00:00:00Z","timestamp":565315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1987,12]]},"abstract":"<jats:p>1. Standard renal clearance techniques were used to investigate the effects of chronic hyperprolactinaemia on kidney function in male, female and ovariectomized female rats. 2. All hyperprolactinaemic rats showed a significantly increased glomerular filtration rate (G.F.R.) compared to controls. Values were (microliter min\u20101) 2738 +\/\u2010 146 vs. 2299 +\/\u2010 99 for males (P less than 0.05), 2236 +\/\u2010 79 vs. 1865 +\/\u2010 74 for females (P less than 0.01) and 2200 +\/\u2010 76 vs. 1941 +\/\u2010 62 for ovariectomized females (P less than 0.05). 3. Hyperprolactinaemic rats in all groups also showed a significant increase in absolute tubular reabsorption of water, sodium and chloride compared to their respective controls. Increases here averaged 19%. 4. There was a significantly greater fractional tubular reabsorption of fluid and solutes in hyperprolactinaemic male rats compared to controls. Values were (%) 92.9 +\/\u2010 0.6 vs. 90.3 +\/\u2010 0.7 for water, 93.0 +\/\u2010 0.4 vs. 91.0 +\/\u2010 0.6 for sodium and 89.9 +\/\u2010 0.7 vs. 86.5 +\/\u2010 0.9 for chloride. In each case P less than 0.05. 5. These results imply an osmoregulatory role for prolactin which is not specific to pregnancy or related female reproductive states.<\/jats:p>","DOI":"10.1113\/jphysiol.1987.sp016857","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:39:17Z","timestamp":1418971157000},"page":"13-21","source":"Crossref","is-referenced-by-count":4,"title":["Altered renal function in chronically hyperprolactinaemic rats."],"prefix":"10.1113","volume":"394","author":[{"given":"H O","family":"Garland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A G","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C M","family":"Milne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1987,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1987.sp016857","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1987.sp016857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T18:18:34Z","timestamp":1697912314000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1987.sp016857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,12]]}},"alternative-id":["10.1113\/jphysiol.1987.sp016857"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1987.sp016857","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,12]]}}}