{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T10:50:32Z","timestamp":1698403832271},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1988,1,1]],"date-time":"1988-01-01T00:00:00Z","timestamp":567993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:p>1. Secretion of [3H]acetylcholine was studied in the guinea\u2010pig ileum longitudinal muscle\u2010myenteric plexus preparation. The transmitter stores of the cholinergic nerves were labelled by pre\u2010incubation with [3H]choline. The preparation was mounted in an organ bath and superfused with Tyrode solution containing hemicholinium\u20103 and eserine. [3H]Acetylcholine secretion was evoked by electrical stimulation (0.5 Hz, 150 shocks). 2. 8\u2010Bromo cyclic AMP, the adenylate cyclase activator forskolin, and the cyclic nucleotide phosphodiesterase inhibitor 3\u2010isobutyl\u20101\u2010methylxanthine enhanced the [3H]acetylcholine secretion in a concentration\u2010dependent manner. The values of 'maximal enhancement' calculated were similar, viz. 200\u2010300% of control. 3. 8\u2010Bromo cyclic GMP reduced the [3H]acetylcholine secretion. 4. The 'maximal enhancement' of 3\u2010isobutyl\u20101\u2010methylxanthine was not altered by the presence of forskolin (25 mumol\/l) suggesting a common mechanism of action, i.e. elevation of endogenous cyclic AMP levels. 5. The muscarinic acetylcholine receptor antagonist atropine enhanced the [3H]acetylcholine secretion with a 'maximal enhancement' of 506% of control. Presence of neither forskolin (25 mumol\/l) nor 3\u2010isobutyl\u20101\u2010methylxanthine (5 mmol\/l) altered the 'maximal enhancement' for atropine. 6. In contrast, atropine (1 mumol\/l) and 4\u2010aminopyridine (0.5 mmol\/l) additively enhanced the [3H]acetylcholine secretion. 7. The results suggest that neuronal cyclic AMP may be involved in muscarinic acetylcholine receptor\u2010mediated control of [3H]acetylcholine secretion in guinea\u2010pig ileum myenteric plexus.<\/jats:p>","DOI":"10.1113\/jphysiol.1988.sp016928","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:35:56Z","timestamp":1418970956000},"page":"441-453","source":"Crossref","is-referenced-by-count":27,"title":["Interaction of forskolin with the effect of atropine on [3H]acetylcholine secretion in guinea\u2010pig ileum myenteric plexus."],"prefix":"10.1113","volume":"395","author":[{"given":"P","family":"Alberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V R","family":"Ogren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1988,1]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1988.sp016928","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1988.sp016928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T12:12:19Z","timestamp":1697976739000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1988.sp016928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1113\/jphysiol.1988.sp016928"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1988.sp016928","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}