{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:33:07Z","timestamp":1762075987641},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1988,7,1]],"date-time":"1988-07-01T00:00:00Z","timestamp":583718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:p>1. The effects of adenosine 5'\u2010triphosphate (ATP) and other adenine compounds were examined on rat papillary and right ventricular muscles in the presence of 10 microM\u2010propranolol, 10 microM\u2010atropine and 0.1 microM\u2010prazosin or 10 microM\u2010phentolamine. 2. Adenosine, adenosine 5'\u2010monophosphate (AMP), adenosine 5'\u2010diphosphate (ADP), ATP and alpha,beta\u2010methylene ATP (APCPP) produced small positive inotropic effects, sometimes preceded by transient negative effects. 3. 8\u2010Phenyltheophylline (8\u2010PT), a P1\u2010purinoceptor antagonist antagonized the negative effects and increased the positive inotropy induced by ATP and adenosine. 4. In the presence of APCPP, a P2\u2010purinergic agonist, ATP had only negative inotropic effects. 5. Adenosine and ATP increased inositol 1, 4, 5\u2010 and inositol 1, 3, 4\u2010trisphosphate as well as inositol mono\u2010 and bisphosphate formation. Maximal effects were obtained at concentrations of 0.5 mM. 6. APCPP increased inositol phosphate formation while 8\u2010PT did not prevent the effects of adenosine and ATP. 7. It is suggested that P2\u2010purinoceptor activation induces both a positive inotropy and an increase in inositol\u2010lipid metabolism in rat ventricular muscles.<\/jats:p>","DOI":"10.1113\/jphysiol.1988.sp017157","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:35:35Z","timestamp":1418970935000},"page":"185-199","source":"Crossref","is-referenced-by-count":78,"title":["ATP and other adenine compounds increase mechanical activity and inositol trisphosphate production in rat heart."],"prefix":"10.1113","volume":"401","author":[{"given":"A","family":"Legssyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Poggioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Renard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Vassort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1988,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1988.sp017157","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1988.sp017157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T15:32:54Z","timestamp":1697902374000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1988.sp017157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,7]]}},"alternative-id":["10.1113\/jphysiol.1988.sp017157"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1988.sp017157","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7]]}}}