{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:58:16Z","timestamp":1771880296745,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1988,9,1]],"date-time":"1988-09-01T00:00:00Z","timestamp":589075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:p>1. The effects of stimulating the postganglionic parasympathetic nerve to the parotid gland, the auriculo\u2010temporal nerve, continuously at 40 Hz for 80 min have been assessed on the flow of saliva and its amylase content during each 10 min period and on the glandular morphology at the end of the stimulation, in female Sprague\u2010Dawley rats under chloralose anaesthesia. Adrenergic responses were blocked by prior administration of dihydroergotamine (1 mg\/kg I.P.) and propranolol (1 mg\/kg I.P.). The contralateral unstimulated parotid gland from each animal was used for morphological control purposes. 2. In normal animals there was a copious flow of saliva reaching 3 ml or more in 80 min. It was well maintained after a gradual small decline and the flow in the last 10 min period was still 60% of that in the initial period. Amylase output was relatively high in the initial period but then declined more rapidly than the flow. The acini were densely packed with granules on the control side and showed a moderate amount of degranulation on the parasympathetically stimulated side. 3. After atropine (2 mg\/kg I.V.), normal animals initially showed a moderate flow of saliva, being 41% of the non\u2010atropinized animals, but there was a rapid decline and the total flow over 80 min was only 15% of that in the non\u2010atropinized animals. The amylase secreted was also high initially and showed a rapid decline; the total amount secreted was similar to that in non\u2010atropinized animals. The morphology was similar to that in non\u2010atropinized animals and showed a similar loss of acinar granules on the stimulated side. 4. Chronic bilateral postganglionic sympathectomy (4\u20106 weeks duration) caused a drastic reduction in the capacity of the gland to secrete saliva in response to parasympathetic stimulation, reaching only one\u2010third of that from normal animals. The initial output of amylase was greater than in normal animals but the total output was similar. The control unstimulated sympathectomized glands appeared similar morphologically to normal resting glands. However, on the parasympathetically stimulated side, besides the usual amount of acinar degranulation, there was also a conspicuous development of acinar vacuolation, not seen in the other groups of animals.(ABSTRACT TRUNCATED AT 400 WORDS)<\/jats:p>","DOI":"10.1113\/jphysiol.1988.sp017241","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:27:02Z","timestamp":1418970422000},"page":"105-116","source":"Crossref","is-referenced-by-count":17,"title":["The effects of atropine and chronic sympathectomy on maximal parasympathetic stimulation of parotid saliva in rats."],"prefix":"10.1113","volume":"403","author":[{"given":"J","family":"Ekstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Garrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"M\u00e5nsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Tobin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1988,9]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1988.sp017241","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1988.sp017241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T12:08:34Z","timestamp":1697976514000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1988.sp017241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1113\/jphysiol.1988.sp017241"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1988.sp017241","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]}}}