{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:33:06Z","timestamp":1762075986976},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1988,12,1]],"date-time":"1988-12-01T00:00:00Z","timestamp":596937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1988,12]]},"abstract":"<jats:p>1. Current\u2010 and voltage\u2010clamp methods were used to evaluate the intracellular and ionic mechanisms involved in dopamine\u2010induced slow depolarizations recorded from neurones of the LB cluster in the abdominal ganglion of Aplysia kurodai. 2. In voltage\u2010clamped cells, dopamine induced a slow inward current that, over the range studied (\u201040 to \u2010110 mV), decreased in amplitude with hyperpolarization of the cell, but failed to invert when the cell was hyperpolarized beyond the reversal potential for K+,(E)K. 3. Bathing the ganglion in 3\u2010isobutyl\u20101\u2010methylxanthine (IBMX) caused a significant increase in the dopamine response. 4. Most of the responses to dopamine were markedly augmented in Ca2+\u2010free media, but were depressed in Na+\u2010free media. 5. An intracellular injection of cyclic adenosine 3',5'\u2010monophosphate (cyclic AMP) into the same cell type produced an inward current which, like the response to dopamine, diminished in amplitude with hyperpolarization of the cell. 6. Like the dopamine response, the cyclic AMP response increased in the presence of IBMX, was enhanced in Ca2+\u2010free media, was depressed in Na+\u2010free media, and was unaffected by changes in external potassium. 7. In a few cells, although the cyclic AMP\u2010induced responses disappeared in Na+\u2010free media, the dopamine\u2010induced slow inward current responses did not. However, these Na+\u2010free resistant responses disappeared completely in Na+\u2010 and Ca2+\u2010free media. 8. It was concluded that most of the dopamine\u2010induced inward current responses were produced by an increase in permeability, mainly to Na+, triggered by a receptor\u2010controlled increase in intracellular cyclic AMP.<\/jats:p>","DOI":"10.1113\/jphysiol.1988.sp017410","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T05:03:53Z","timestamp":1418965433000},"page":"199-213","source":"Crossref","is-referenced-by-count":20,"title":["Dopamine\u2010induced depolarizing responses associated with negative slope conductance in LB\u2010cluster neurones of Aplysia."],"prefix":"10.1113","volume":"407","author":[{"given":"M","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Shozushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1988,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1988.sp017410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1988.sp017410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T06:41:39Z","timestamp":1697956899000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1988.sp017410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,12]]}},"alternative-id":["10.1113\/jphysiol.1988.sp017410"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1988.sp017410","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,12]]}}}