{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:34:01Z","timestamp":1760985241724},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1989,8,1]],"date-time":"1989-08-01T00:00:00Z","timestamp":617932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1989,8]]},"abstract":"<jats:p>1. Secretory responses of ferret parotid and submandibular glands were investigated in the presence of muscarinic, alpha\u2010 and beta\u2010adrenoceptor blocking agents. 2. In pentobarbitone\u2010anaesthetized animals I.V. doses of vasoactive intestinal peptide (VIP) failed to elicit overt secretion of saliva from either gland. 3. However, an occult secretion of protein occurred in response to VIP from both types of gland. This was revealed by means of a subsequent I.V. wash\u2010out injection of substance P, which is a potent secretagogue in ferrets. This effect of VIP was much more marked in the submandibular than in the parotid gland. 4. Electrical stimulation of the chorda\u2010lingual nerve gave rise to protein secretion in the submandibular gland at subthreshold frequencies for overt non\u2010cholinergic, non\u2010adrenergic secretion of saliva, as revealed by subsequent wash\u2010out I.V. injection of substance P. 5. Protein secretion in response to VIP was also demonstrated in vitro by perifusing small pieces of the two glands. The sensitivity of submandibular tissue to VIP greatly exceeded that of the parotid tissue. 6. It is concluded that VIP, or a structurally related peptide, may be involved in the non\u2010cholinergic, non\u2010adrenergic secretory response of ferret salivary glands evoked by parasympathetic nerve stimulation.<\/jats:p>","DOI":"10.1113\/jphysiol.1989.sp017715","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T00:26:19Z","timestamp":1418948779000},"page":"131-141","source":"Crossref","is-referenced-by-count":26,"title":["Secretion of protein from salivary glands in the ferret in response to vasoactive intestinal peptide."],"prefix":"10.1113","volume":"415","author":[{"given":"J","family":"Ekstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Tobin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,8]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1989.sp017715","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1989.sp017715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T01:02:24Z","timestamp":1697936544000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1989.sp017715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,8]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,8]]}},"alternative-id":["10.1113\/jphysiol.1989.sp017715"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1989.sp017715","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,8]]}}}