{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:22:57Z","timestamp":1756995777938},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1989,9,1]],"date-time":"1989-09-01T00:00:00Z","timestamp":620611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:p>1. Intracellular recordings were made from submucous neurones of the guinea\u2010pig caecum. In most experiments, membrane currents were measured using a single\u2010electrode voltage clamp. 2. A potassium current dependent on calcium influx occurred at rest (approximately equal to 200 pA at \u201060 mV). The amplitude of the current was increased up to 1 nA at \u201035 mV and decreased to zero at \u2010100 mV; when fully activated the current did not show any inactivation. An inward calcium current, of 15\u201025 pA in amplitude near \u201060 mV and insensitive to omega\u2010conotoxin (0.5 microM), probably activated the potassium current. 3. Step depolarizations from potentials negative to \u201080 mV evoked a transient (less than or equal to 200 ms at \u201040 mV) potassium current which was blocked by 4\u2010aminopyridine (1\u20103 mM). Hyperpolarizing commands to potentials negative to \u201087 mV evoked an inwardly rectifying potassium current which was selectively blocked by caesium (1\u20102 mM). The residual cell current between \u2010100 and \u201040 mV in calcium\u2010free solution containing tetraethylammonium (20 mM), caesium (2 mM) and 4\u2010amino\u2010pyridine (3 mM) conformed to constant field assumptions. This current was called a background potassium current. 4. Decrease in membrane conductance during the slow excitatory postsynaptic current (EPSC) was due predominantly (greater than or equal to 90%) to a reduction in the calcium\u2010activated potassium current at \u201035 mV, but due almost exclusively to a reduction in the background potassium current at potentials more negative than \u2010100 mV. The relative contribution of the two currents to the slow EPSC was entirely dependent on the relative contribution of the currents to the membrane conductance at given potentials. 5. The transient potassium current was unaffected or slightly enhanced during the slow EPSC. The inwardly rectifying potassium current was unaffected during the slow EPSC. 6. Three tachykinins (substance P, substance K and neurokinin B; 3\u2010800 nM), forskolin (1\u201030 microM), 8\u2010bromoadenosine 3':5'\u2010cyclic monophosphate (8\u2010bromo cyclic AMP; 1\u20103 mM), 3\u2010isobutyl\u20101\u2010methylxanthine (0.3\u20101 mM) mimicked the conductance changes during the slow EPSC in a concentration\u2010dependent manner. 7. It is concluded that the slow excitatory synaptic potential in the submucous plexus, presumably mediated by peptidergic transmitters, results from an inactivation of two distinct potassium currents, at least one of which is controlled by intracellular calcium ions.<\/jats:p>","DOI":"10.1113\/jphysiol.1989.sp017778","type":"journal-article","created":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T23:44:17Z","timestamp":1418946257000},"page":"571-588","source":"Crossref","is-referenced-by-count":23,"title":["Potassium currents in submucous neurones of guinea\u2010pig caecum and their synaptic modification."],"prefix":"10.1113","volume":"416","author":[{"given":"T","family":"Akasu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Tokimasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,9]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1989.sp017778","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1989.sp017778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T00:47:51Z","timestamp":1697935671000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1989.sp017778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,9]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,9]]}},"alternative-id":["10.1113\/jphysiol.1989.sp017778"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1989.sp017778","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,9]]}}}