{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:58:23Z","timestamp":1759147103302},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1989,10,1]],"date-time":"1989-10-01T00:00:00Z","timestamp":623203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:p>1. Synaptic currents and responses to acetylcholine (ACh) were recorded from mouse submandibular ganglion (SMG) cells under whole\u2010cell voltage clamp. 2. The peak amplitude of excitatory synaptic currents (ESCs) as well as the currents evoked by the ionophoretic application of ACh followed a unique non\u2010linear current\u2010voltage (I\u2010V) relation. The chord conductance of the whole\u2010cell currents decreased with depolarization of the membrane potential and became virtually 0 at 50 mV. 3. The decay of ESCs was described by two exponential functions. Both the fast (tau f) and slow (tau s) time constants were sharply decreased at depolarizing potentials beyond \u201040 mV, being insensitive to hyperpolarizing potentials more than \u201050 mV. 4. Single ACh receptor channels were characterized by the whole\u2010cell current noise analysis. The single\u2010channel currents followed Ohm's law at negative membrane potentials but tended to reach a plateau at positive membrane potentials. The mean slope conductance measured between \u201040 and \u201020 mV was 28.5 pS. 5. The product of the number of functional channels (N) and the probability of a channel being open (p) showed a steep voltage dependence. The value of Np at 20 mV was only 31% of that at \u201020 mV. 6. The noise power spectrum was best fitted by a double\u2010Lorentzian function. Both the fast (tau f) and slow (tau s) time constants were sharply decreased by depolarizations beyond \u201020 mV. being less sensitive to membrane potentials more negative than \u201030 mV. 7. The non\u2010linear I\u2010V relation of ESCs was attributed in part to the voltage dependence of p and in part to the voltage dependence of the single\u2010channel conductance (gamma) of ACh receptor channels.<\/jats:p>","DOI":"10.1113\/jphysiol.1989.sp017803","type":"journal-article","created":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T22:59:10Z","timestamp":1418943550000},"page":"307-322","source":"Crossref","is-referenced-by-count":27,"title":["Rectification of synaptic and acetylcholine currents in the mouse submandibular ganglion cells."],"prefix":"10.1113","volume":"417","author":[{"given":"H","family":"Yawo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,10]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1989.sp017803","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1989.sp017803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T04:24:59Z","timestamp":1697948699000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1989.sp017803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,10]]}},"alternative-id":["10.1113\/jphysiol.1989.sp017803"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1989.sp017803","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,10]]}}}