{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:25:41Z","timestamp":1789730741449,"version":"4.0.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1990,3,1]],"date-time":"1990-03-01T00:00:00Z","timestamp":636249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:p>1. The whole\u2010cell configuration of the patch\u2010clamp technique was used to record K+ currents from type I cells enzymatically dispersed from the neonatal rat carotid body. The current\u2010voltage (I\u2010V) relationship for the K+ currents showed a prominent, outward shoulder at test potentials of between +10 and +30 mV. 2. The shoulder of the I\u2010V curve could be enhanced by raising extracellular Ca2+ concentration or by bath application of 5 microM\u2010Bay K 8644. It could also be suppressed by bath application of 100 microM\u2010Cd2+ or 5 microM\u2010methoxyverapamil (D600), indicating that a large component of the K+ current in these cells was activated by an influx of Ca2+ through its own channels during cell depolarization. 3. Potassium currents were also reversibly suppressed by 8 nM\u2010charybdotoxin but unaffected by 100 nM\u2010apamin, suggesting that the Ca2(+)\u2010dependent K+ current was carried through large or intermediate conductance Ca2(+)\u2010activated K+ channels. 4. Lowering the pH of the bathing medium from 7.40 to 7.00 reversibly reduced the K+ current amplitudes, and suppressed the shoulder normally seen in the I\u2010V relationship. This effect was enhanced in the presence of 5 microM\u2010Bay K 8644 and abolished in the presence of 5 microM\u2010D600. 5. It is concluded that the Ca2(+)\u2010dependent K+ channels of type I carotid body cells are selectively suppressed by extracellular acidity. Possible mechanisms underlying this effect, and its role in excitation of the carotid body are discussed.<\/jats:p>","DOI":"10.1113\/jphysiol.1990.sp017990","type":"journal-article","created":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T12:57:11Z","timestamp":1418907431000},"page":"381-395","source":"Crossref","is-referenced-by-count":61,"title":["Effect of lowered extracellular pH on Ca2(+)\u2010dependent K+ currents in type I cells from the neonatal rat carotid body."],"prefix":"10.1113","volume":"422","author":[{"given":"C","family":"Peers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1990,3]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1990.sp017990","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1990.sp017990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T10:29:17Z","timestamp":1697970557000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1990.sp017990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["10.1113\/jphysiol.1990.sp017990"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1990.sp017990","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3]]}}}