{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:40:40Z","timestamp":1762101640863},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1991,6,1]],"date-time":"1991-06-01T00:00:00Z","timestamp":675734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:p>1. Neurokinin A (NKA) is a mammalian tachykinin distributed principally in the nervous system, including the myenteric innervation of the gut. 2. NKA may be involved in neurogenic inflammation and as a modulatory factor in the diarrhoea associated with mucosal inflammation of inflammatory bowel disease (ulcerative colitis). 3. We evaluated the effect of NKA on the short\u2010circuit current ISC, assumed to reflect electrogenic chloride secretion, across muscle\u2010stripped rat colonic mucosa mounted in Ussing chambers. 4. Serosal addition of NKA produced a concentration\u2010dependent (0.1\u2010100 nM) increase in ISC with an EC50 (half\u2010maximal effective concentration) value of 7.5 nM. The maximum (mean +\/\u2010 S.E.M.) increase in ISC (microA\/cm2) for NKA was 111 +\/\u2010 10. 5. Tetrodotoxin (0.5 microM) and bumetanide (10 microM), but not atropine (1.0 microM), hexamethonium (100 microM) or pyrilamine (10 microM), significantly inhibited NKA\u2010induced increases in ISC. 6. The response to NKA was attenuated by 45 min pre\u2010treatment with antisera raised against vasoactive intestinal polypeptide (VIP). Moreover, prior desensitization to VIP attenuated the effect of NKA. 7. These studies suggest that NKA increases ISC in rat colon, in part, through a non\u2010cholinergic neural mechanism involving VIP.<\/jats:p>","DOI":"10.1113\/jphysiol.1991.sp018599","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T21:27:43Z","timestamp":1418851663000},"page":"341-350","source":"Crossref","is-referenced-by-count":15,"title":["Neurokinin A increases short\u2010circuit current across rat colonic mucosa: a role for vasoactive intestinal polypeptide."],"prefix":"10.1113","volume":"437","author":[{"given":"X Y","family":"Tien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L J","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F","family":"Kachur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Won\u2010Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T S","family":"Gaginella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1991.sp018599","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1991.sp018599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:05:41Z","timestamp":1698041141000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1991.sp018599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,6]]}},"alternative-id":["10.1113\/jphysiol.1991.sp018599"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1991.sp018599","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,6]]}}}