{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:16:17Z","timestamp":1761394577020},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1991,10,1]],"date-time":"1991-10-01T00:00:00Z","timestamp":686275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:p>1. The influence of the delta\u2010opioid receptor agonist (D\u2010Ser2)\u2010leu\u2010enkephalin (Thr6) (DSLET) on different spinal reflex pathways was investigated in anaemically decapitated, high spinal cats. Monosynaptic reflexes were tested to analyse excitatory and inhibitory flexor reflex afferent (FRA) pathways from nociceptive (from the skin of the central pad) and non\u2010nociceptive (from skin, joint or group II muscle) afferents, as well as an excitatory nociceptive non\u2010FRA pathway from the central pad to plantaris and intrinsic foot extensors and the inhibitory pathway from Ib muscle afferents. 2. DSLET suffused over the spinal cord (concentration 10(\u20103)\u201010(\u20106) M) caused a concentration\u2010dependent depression of transmission in nociceptive and non\u2010nociceptive FRA pathways. The excitatory FRA pathways including those from group II muscle afferents were more sensitive than the inhibitory ones. The nociceptive non\u2010FRA pathway from the central pad to plantaris and intrinsic foot extensors was less affected than the FRA pathways. The inhibitory pathway from Ib muscle afferents remained almost unaffected. 3. Intravenous injection of DSLET (0.5\u20103.6 mg\/kg) induced dose\u2010dependent effects similar to those from local spinal application. The main difference was that I.V. injection more readily caused depression of the inhibitory FRA pathways to extensors. 4. The effects of local spinal application and of I.V. injection of DSLET were antagonized by I.V. injection of naloxone (0.1\u20101 mg\/kg). 5. The effects of DSLET on spinal reflex pathways in many respects resemble that of monoamines. Possibly there is an interaction and a co\u2010operation of enkephalins and monoamines in motor control.<\/jats:p>","DOI":"10.1113\/jphysiol.1991.sp018785","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T17:22:01Z","timestamp":1418836921000},"page":"103-126","source":"Crossref","is-referenced-by-count":24,"title":["Limitedly selective action of a delta\u2010agonistic leu\u2010enkephalin on the transmission in spinal motor reflex pathways in cats."],"prefix":"10.1113","volume":"442","author":[{"given":"P F","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E D","family":"Schomburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Steffens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,10]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1991.sp018785","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1991.sp018785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T11:20:27Z","timestamp":1698060027000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1991.sp018785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,10]]}},"alternative-id":["10.1113\/jphysiol.1991.sp018785"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1991.sp018785","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10]]}}}