{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:59:26Z","timestamp":1758815966105},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1991,11,1]],"date-time":"1991-11-01T00:00:00Z","timestamp":688953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:p>1. Intracerebroventricular (I.C.V.) infusion (60 ng h\u20101) of Isoleu5\u2010angiotensin II (Isoleu5\u2010\u2010AngII) and des\u2010amine\u2010angiotensin II (des\u2010amine\u2010AngII) in rats caused increased drinking behaviour and an increase in arterial blood pressure. 2. Des\u2010amine\u2010AngII caused similar increases in heart rate and arterial blood pressure as AngII. 3. Previous I.C.V. injection of the antagonists [Leu8]\u2010AngII, des\u2010amine\u2010[Leu8]\u2010AngII and octanoyl\u2010[Leu8]\u2010AngII prevented the increases in heart rate and blood pressure produced by I.C.V. infusion of AngII and caused partial reduction of the dipsogenic response. 4. The three antagonists had no effect on the increase in arterial blood pressure and heart rate caused by des\u2010amine\u2010AngII. The drinking response was reduced by previous injection of [Leu8]\u2010AngII and des\u2010amine\u2010[Leu8]\u2010AngII but not by octanoyl\u2010[Leu8]\u2010AngII. 5. In conclusion, Isoleu5\u2010AngII and des\u2010amine\u2010AngII increase drinking behaviour, arterial blood pressure and heart rate when infused into the cerebral ventricle of rats. The study with the antagonists showed that des\u2010amine\u2010AngII probably binds more strongly to AngII\u2010receptors.<\/jats:p>","DOI":"10.1113\/jphysiol.1991.sp018848","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T17:15:31Z","timestamp":1418836531000},"page":"513-518","source":"Crossref","is-referenced-by-count":1,"title":["The effect of analogues of angiotensin II on drinking and cardiovascular responses to central angiotensin II in the rat."],"prefix":"10.1113","volume":"443","author":[{"given":"L A","family":"Camargo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"L A","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J V","family":"Menani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Renzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W A","family":"Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W A","family":"Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,11]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1991.sp018848","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1991.sp018848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T04:56:06Z","timestamp":1698036966000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1991.sp018848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,11]]}},"alternative-id":["10.1113\/jphysiol.1991.sp018848"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1991.sp018848","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11]]}}}