{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:20:25Z","timestamp":1791080425703,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:p>1. We have studied the kinetics of inactivation of sodium currents evoked in Schwann cells from neonatal and adult rabbits with patch\u2010clamp recording techniques. The decay both of whole\u2010cell currents and of ensemble currents obtained from outside\u2010out patches was reasonably well\u2010described by single exponential fits which gave values for the time constant, tau h, similar to those found for such currents in nerve (about 0.5 ms at 0 mV). Although inclusion of an additional exponential component usually improved the fits to the decay of these currents, the relative amplitude of the slower component (time constant 3\u20106 ms) was always small. 2. The time course of recovery from steady\u2010state inactivation clearly consisted of two exponential components. At \u2010120 mV, recovery from steady\u2010state inactivation at \u201050 mV consisted of a fast component with a time constant of 2.2 +\/\u2010 0.2 ms and a much slower component with a time constant of 1.2 +\/\u2010 0.2 s (n = 9). The relative amplitude of the slow component (expressed as a fraction of the sodium current when inactivation was removed completely) was 0.56 +\/\u2010 0.03. The corresponding amplitudes of the slow component when similar experiments were done from holding potentials of 0 and \u201070 mV were 0.80 +\/\u2010 0.04 and 0.36 +\/\u2010 0.03, respectively (n = 5 and 8). 3. The onset of steady\u2010state inactivation also followed a bi\u2010exponential time course. The time constant of the slower component was similar at each potential examined (0, \u201050 and \u201070 mV), being 6\u20107 s. The relative amplitude of the slow component of onset depended on membrane potential, and it was similar (at each potential examined) to the corresponding amplitude of the slow component of recovery. 4. The inclusion of 40 mM\u2010iodate ions in the pipette solution slowed the decay of whole\u2010cell sodium currents, as did the extracellular application of venom (10 micrograms ml\u20101) from the scorpion Leiurus quinquestriatus. Prolonged exposure of the cells to Leiurus venom appeared to increase the steady\u2010state amount of slow inactivation. 5. Records of single\u2010channel sodium currents tended to cluster into records which either did, or did not, contain openings. This apparently non\u2010random behaviour depended on membrane potential, and on the frequency at which the test steps were repeated, in the way expected if it resulted from slow inactivation.(ABSTRACT TRUNCATED AT 400 WORDS)<\/jats:p>","DOI":"10.1113\/jphysiol.1992.sp019315","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T15:34:42Z","timestamp":1418830482000},"page":"529-566","source":"Crossref","is-referenced-by-count":30,"title":["Multiple kinetic components of sodium channel inactivation in rabbit Schwann cells."],"prefix":"10.1113","volume":"455","author":[{"given":"J R","family":"Howe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1992,9]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1992.sp019315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1992.sp019315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T14:12:27Z","timestamp":1698070347000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1992.sp019315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1113\/jphysiol.1992.sp019315"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1992.sp019315","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}