{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:46:09Z","timestamp":1778733969330,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1993,3,1]],"date-time":"1993-03-01T00:00:00Z","timestamp":730944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:p>1. Intracellular recordings were made from submucosal neurones and single\u2010electrode voltage\u2010clamp methods were used to record membrane currents. The actions of substance P (SP), 5\u2010hydroxytryptamine (5\u2010HT), muscarine, vasoactive intestinal polypeptide (VIP), forskolin and nerve stimulation were studied. 2. Substance P, 5\u2010HT (in the presence of 5\u2010HT3 receptor antagonists), muscarine, VIP, forskolin and slow excitatory synaptic transmission all produced identical responses: an inward current associated with a membrane conductance decrease at the resting potential. The actions of any one occluded the actions of any other and all responses were pertussis\u2010toxin insensitive. 3. These agonists produced a voltage\u2010independent decrease in a \u2018leak\u2019 potassium conductance between \u201040 and \u2010120 mV in 14% of neurones. 4. These agonists decreased a voltage\u2010dependent, calcium\u2010activated potassium conductance between \u201040 and \u201080 mV in all other (86%) neurones. The agonists still evoked an inward current without apparent conductance change at potentials between \u201090 and \u2010130 mV. 5. In a low calcium solution containing cobalt or cadmium, the agonists produced an inward current associated with a conductance increase from \u201040 to \u2010120 mV. Ion replacement studies indicated this current was due to an increase in a cation\u2010selective (mainly sodium) conductance. 6. The agonists also reduced the inwardly rectifying potassium current that is activated by somatostatin and alpha 2\u2010adrenoceptor agonists in these neurones. The agonists did not alter the inwardly rectifying potassium current that is present in these neurones in the absence of somatostatin or alpha 2\u2010agonists. 7. Thus, SP, 5\u2010HT, muscarine, VIP and the release of slow excitatory transmitters all appear to act through a common intracellular transduction pathway, an increase in adenylate cyclase. This results in an activation of a sodium\u2010selective cation current and an inhibition of three distinct potassium conductances: the background potassium conductance, the calcium\u2010activated potassium conductance and the inwardly rectifying potassium conductance activated by somatostatin and alpha 2\u2010adrenoceptor agonists.<\/jats:p>","DOI":"10.1113\/jphysiol.1993.sp019565","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T14:44:40Z","timestamp":1418827480000},"page":"483-501","source":"Crossref","is-referenced-by-count":38,"title":["Common ionic mechanisms of excitation by substance P and other transmitters in guinea\u2010pig submucosal neurones."],"prefix":"10.1113","volume":"462","author":[{"given":"K Z","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Surprenant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,3]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1993.sp019565","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1993.sp019565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T17:48:53Z","timestamp":1698256133000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1993.sp019565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["10.1113\/jphysiol.1993.sp019565"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1993.sp019565","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]}}}