{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:07:42Z","timestamp":1761581262251},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:p>1. GABA receptor\u2010modulating drugs and intracellular recording techniques were used to determine the functional significance of peripheral afferent GABA\u2010containing nerves projecting from the distal colon to sympathetic neurones in the inferior mesenteric ganglion of the guinea\u2010pig. 2. GABAA receptor\u2010modulating drugs added selectively to the inferior mesenteric ganglion side of a two\u2010compartment bath had pronounced effects on on\u2010going colonic afferent cholinergic synaptic input. Bicuculline (20 microM) decreased the amplitude and frequency of fast excitatory postsynaptic potentials (EPSPs) by 40% whereas diazepam (5 microM) increased cholinergic input by 43%. Neither drug had any effect on the resting membrane potential or membrane input resistance of ganglion cells. 3. Bicuculline (20 microM) significantly reduced, whereas diazepam (5 microM) significantly enhanced, distension\u2010induced increases in nicotinic fast EPSPs and action potentials. 4. Slow EPSPs evoked by colonic distension were not affected by bicuculline or diazepam. 5. Manual voltage clamp of the postsynaptic depolarizing response to exogenous GABA revealed GABA\u2010induced presynaptic facilitation of colonic afferent but not central preganglionic efferent cholinergic synaptic input. 6. The data suggest that endogenously released GABA participates in on\u2010going colo\u2010colonic reflex activity by acting on presynaptic GABAA receptors to facilitate release of acetylcholine from colonic mechanosensory nerves.<\/jats:p>","DOI":"10.1113\/jphysiol.1993.sp019896","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T13:42:06Z","timestamp":1418823726000},"page":"175-189","source":"Crossref","is-referenced-by-count":12,"title":["The electrophysiological effects of endogenous GABA in the guinea\u2010pig inferior mesenteric ganglion."],"prefix":"10.1113","volume":"471","author":[{"given":"W H","family":"Stapelfeldt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H P","family":"Parkman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Szurszewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,11]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1993.sp019896","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1993.sp019896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T23:57:47Z","timestamp":1698191867000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1993.sp019896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["10.1113\/jphysiol.1993.sp019896"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1993.sp019896","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11]]}}}