{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:24:30Z","timestamp":1791127470081,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1994,2,1]],"date-time":"1994-02-01T00:00:00Z","timestamp":760060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:p>1. We studied eight young men (age range: 20\u201037 years) with chronic, clinically complete high cervical spinal cord injuries and ten age\u2010matched healthy men to determine how interruption of connections between the central nervous system and spinal sympathetic motoneurones affects autonomic cardiovascular control. 2. Baseline diastolic pressures and R\u2010R intervals (heart periods) were similar in the two groups. Slopes of R\u2010R interval responses to brief neck pressure changes were significantly lower in tetraplegic than in healthy subjects, but slopes of R\u2010R interval responses to steady\u2010state arterial pressure reductions and increases were comparable. Plasma noradrenaline levels did not change significantly during steady\u2010state arterial pressure reductions in tetraplegic patients, but rose sharply in healthy subjects. The range of arterial pressure and R\u2010R interval responses to vasoactive drugs (nitroprusside and phenylephrine) was significantly greater in tetraplegic than healthy subjects. 3. Resting R\u2010R interval spectral power at respiratory and low frequencies was similar in the two groups. During infusions of vasoactive drugs, low\u2010frequency R\u2010R interval spectral power was directly proportional to arterial pressure in tetraplegic patients, but was unrelated to arterial pressure in healthy subjects. Vagolytic doses of atropine nearly abolished both low\u2010 and respiratory\u2010frequency R\u2010R interval spectral power in both groups. 4. Our conclusions are as follows. First, since tetraplegic patients have significant levels of low\u2010frequency arterial pressure and R\u2010R interval spectral power, human Mayer arterial pressure waves may result from mechanisms that do not involve stimulation of spinal sympathetic motoneurones by brainstem neurones. Second, since in tetraplegic patients, low\u2010frequency R\u2010R interval spectral power is proportional to arterial pressure, it is likely to be mediated by a baroreflex mechanism. Third, since low\u2010frequency R\u2010R interval rhythms were nearly abolished by atropine in both tetraplegic and healthy subjects, these rhythms reflect in an important way rhythmic firing of vagal cardiac motoneurones.<\/jats:p>","DOI":"10.1113\/jphysiol.1994.sp020039","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T13:13:58Z","timestamp":1418822038000},"page":"483-495","source":"Crossref","is-referenced-by-count":142,"title":["Human autonomic rhythms: vagal cardiac mechanisms in tetraplegic subjects."],"prefix":"10.1113","volume":"474","author":[{"given":"J","family":"Koh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T E","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L A","family":"Beightol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Y","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D L","family":"Eckberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1994,2]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1994.sp020039","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1994.sp020039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:22:32Z","timestamp":1698106952000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1994.sp020039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,2]]}},"alternative-id":["10.1113\/jphysiol.1994.sp020039"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1994.sp020039","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}