{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:01:27Z","timestamp":1759683687900},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1994,4,15]],"date-time":"1994-04-15T00:00:00Z","timestamp":766368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1994,4,15]]},"abstract":"<jats:p>The effects of calcium channel blockers on potassium\u2010induced transmitter release were studied in thin slices of cerebellum from neonatal rats using whole\u2010cell patch clamp methods. Miniature inhibitory postsynaptic currents (mIPSCs) mediated by gamma\u2010aminobutyric acid (GABA) were recorded from deep cerebellar nuclear neurones in the presence of tetrodotoxin. The frequency of mIPSCs was reproducibly increased by a brief application of high\u2010potassium solution. In the presence of the L\u2010type Ca2+ channel blocker nicardipine (10 microM), the potassium\u2010induced increase in mIPSC frequency was suppressed by 49%. Neither the mean amplitude nor the time course of mIPSCs was affected by the blocker. The N\u2010type Ca2+ channel blocker omega\u2010conotoxin GVIA (omega\u2010CgTX, 3 microM) had no effect on the frequency of potassium\u2010induced mIPSCs. The P\u2010type Ca2+ channel blocker omega\u2010Aga\u2010IVA (200 nM) suppressed the potassium\u2010induced increase in mIPSC frequency by 83% without affecting the mean amplitude or time course of mIPSCs. Comparing these data with previous studies of neurally evoked transmission, it is concluded that the Ca2+ channel subtypes responsible for potassium\u2010induced transmitter release may be different from those mediating fast synaptic transmission.<\/jats:p>","DOI":"10.1113\/jphysiol.1994.sp020123","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T12:45:15Z","timestamp":1418820315000},"page":"197-202","source":"Crossref","is-referenced-by-count":39,"title":["Calcium channels responsible for potassium\u2010induced transmitter release at rat cerebellar synapses."],"prefix":"10.1113","volume":"476","author":[{"given":"A","family":"Momiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,4,15]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1994.sp020123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1994.sp020123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:06:03Z","timestamp":1698109563000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1994.sp020123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4,15]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,4,15]]}},"alternative-id":["10.1113\/jphysiol.1994.sp020123"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1994.sp020123","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4,15]]}}}