{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:21:53Z","timestamp":1789201313700,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1994,4,15]],"date-time":"1994-04-15T00:00:00Z","timestamp":766368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1994,4,15]]},"abstract":"<jats:p>Excitatory postsynaptic currents (EPSCs) were recorded from the medium spiny neurones of neonatal rat striatal slices using the whole\u2010cell patch clamp method. EPSCs were selectively elicited in the presence of picrotoxin with a glass stimulating pipette placed in the striatum. We found two distinct unitary EPSCs that were evoked by stimulation of single presynaptic fibres. The major type of EPSC, termed \u2018S\u2010type\u2019, failed frequently and had a small mean amplitude (2.05 pA). They probably represented cortical afferents. The other type of unitary EPSC, the \u2018H\u2010type\u2019, seldom failed and was 13 times larger than the S\u2010type. Spontaneous EPSCs with amplitudes similar to those of H\u2010type EPSCs could be induced. H\u2010type EPSCs were mediated by both non\u2010NMDA and NMDA receptors. The two types of EPSCs could be evoked in the same neurons. The intensity of stimulation for H\u2010type EPSCs was higher than that for S\u2010type EPSCs. H\u2010type EPSCs could be polysynaptically activated, suggesting the presence of glutamatergic interneurones in the striatum that generated H\u2010type EPSCs. H\u2010type EPSCs displayed particularly long\u2010lasting paired\u2010pulse depression, while that displayed by the S\u2010type EPSCs was short. The paired\u2010pulse depression of both EPSCs was Ca2+ dependent and involved presynaptic mechanisms. We have demonstrated that the medium spiny neurones of neonatal rats receive two different glutamatergic input systems having different amplitudes, origins and paired\u2010pulse depression, reminiscent of cerebellar Purkinje cells. This suggests that the two types of EPSCs also play distinctive roles in striatal neuronal circuitry.<\/jats:p>","DOI":"10.1113\/jphysiol.1994.sp020125","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T12:45:15Z","timestamp":1418820315000},"page":"217-228","source":"Crossref","is-referenced-by-count":30,"title":["Two distinct glutamatergic synaptic inputs to striatal medium spiny neurones of neonatal rats and paired\u2010pulse depression."],"prefix":"10.1113","volume":"476","author":[{"given":"A","family":"Mori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1994,4,15]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1994.sp020125","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1994.sp020125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:06:08Z","timestamp":1698109568000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1994.sp020125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4,15]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,4,15]]}},"alternative-id":["10.1113\/jphysiol.1994.sp020125"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1994.sp020125","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4,15]]}}}