{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:20:05Z","timestamp":1752549605194},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1994,6,15]],"date-time":"1994-06-15T00:00:00Z","timestamp":771638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1994,6,15]]},"abstract":"<jats:p>1. A new method of measuring fluid and ionic movements and the dehydrating power of the colon in vivo is described. A range of agarose gel cylinders, with calibrated hydraulic conductivities (Lp), were inserted into the lumen of the descending colon of anaesthetized rats. Fluxes of fluid, Na+ and K+ out of the gels were measured over a period of 60\u2010110 min. 2. Fluid absorption by the colon from 2.5% agarose gels was not slower than from solution without gel. Fluid absorption was inhibited by 66% when the agarose concentration was raised to 10%. In contrast 2.5% agarose gels caused a 73% (P &lt; 0.001) reduction in water flow from rat ileum. 3. Increasing gel concentration to 10% or above caused the absorbate from the gels to become hypertonic (P &lt; 0.001). 4. The measured suction pressure applied by the colonic hypertonic absorbate to the gels increased from 44 +\/\u2010 2.3 cmH2O (n = 23) with 2.5% agarose gels to 6713 +\/\u2010 960 cmH2O (n = 13) with 15% (P &lt; 0.001). 5. Deoxycholate (2 mM) produced a decrease in fluid and Na+ absorption and reduced the suction pressure and power exerted by the colon.<\/jats:p>","DOI":"10.1113\/jphysiol.1994.sp020214","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T12:35:57Z","timestamp":1418819757000},"page":"539-548","source":"Crossref","is-referenced-by-count":16,"title":["Effects on fluid and Na+ flux of varying luminal hydraulic resistance in rat colon in vivo."],"prefix":"10.1113","volume":"477","author":[{"given":"P S","family":"Zammit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Mendizabal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Naftalin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,6,15]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1994.sp020214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1994.sp020214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T11:31:54Z","timestamp":1698233514000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1994.sp020214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,6,15]]}},"alternative-id":["10.1113\/jphysiol.1994.sp020214"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1994.sp020214","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6,15]]}}}