{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:49:47Z","timestamp":1773082187715,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1994,11,1]],"date-time":"1994-11-01T00:00:00Z","timestamp":783648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:p>1. Isolated superfused rat atrial preparations were used to study the mechanism of stretch\u2010induced atrial natriuretic peptide (ANP) secretion. The stretch of the atrial myocytes was induced by raising the intra\u2010atrial pressure. The secretion rates were analysed by measuring ANP concentrations from the superfusate fractions by radioimmunoassay. 2. The effect of gadolinium, a blocker of stretch\u2010activated ion channels, on stretch\u2010induced and basal ANP secretion was investigated by superfusing the atrial preparation with 5, 20 or 80 microM GdCl3. Gadolinium decreased stretch\u2010induced ANP secretion in a dose\u2010dependent manner, but did not affect basal secretion. 3. Because high concentrations of gadolinium may block voltage\u2010gated calcium channels, we tested whether the selective blockers of L\u2010type (diltiazem) and T\u2010type (NiCl2) calcium channels affect the stretch\u2010stimulated ANP release. Neither diltiazem at 3 microM nor NiCl2 at 50 microM affected stretch\u2010induced ANP release in paced atrial preparation. 4. Gadolinium, but not diltiazem, also inhibited stretch\u2010stimulated ANP secretion in non\u2010paced, quiescent atria. 5. The findings that ANP release is inhibited by Gd3+, but not by diltiazem or NiCl2, and that the stretch\u2010induced secretion in quiescent atria is also inhibited by Gd3+, suggest that stretch\u2010activated ion channels are involved in the regulation of stretch\u2010induced ANP release.<\/jats:p>","DOI":"10.1113\/jphysiol.1994.sp020383","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T11:54:40Z","timestamp":1418817280000},"page":"553-561","source":"Crossref","is-referenced-by-count":45,"title":["Block of stretch\u2010activated atrial natriuretic peptide secretion by gadolinium in isolated rat atrium."],"prefix":"10.1113","volume":"480","author":[{"given":"M","family":"Laine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Arjamaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Vuolteenaho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Ruskoaho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Weckstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,11]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1994.sp020383","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1994.sp020383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T09:21:53Z","timestamp":1698139313000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1994.sp020383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,11]]}},"alternative-id":["10.1113\/jphysiol.1994.sp020383"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1994.sp020383","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,11]]}}}